Explore the Relationship Between Heart Rate Variability, Body Mass Index, Inflammation, and Insulin Resistance.
- Conditions
- Insulin ResistanceOverweightObesity
- Interventions
- Behavioral: aerobic exercise(AE)
- Registration Number
- NCT05949710
- Lead Sponsor
- National Tainan Junior College of Nursing
- Brief Summary
The findings will serve as a reference for clinical professionals to promote exercise among the general population for improving HRV.
- Detailed Description
Background: Heart rate variability (HRV) measurement is widely used to assess the function of cardiac autonomic modulation. Aerobic exercise (AE) has been proven to improve HRV. However, because HRV is highly associated with visceral fat, inflammatory status, and insulin resistance, whether baseline body inflammation status can explain the heterogeneous response to AE remains unknown.
Purposes: We will compare the effects of AE training in improving HRV, inflammatory markers, and insulin resistance between community residents with normal weight and overweight/obesity.
Methods: A quasi-experimental study with purposive sampling will be used to recruit community residents aged 40-64 years with inactive habits in southern Taiwan. The minimum targeted sample size is 43 participants. The participants will be grouped into normal weight and overweight/obese groups. All participants will receive AE training with at least moderate intensity three times per week. HRV parameters, blood samples, and visceral fat will be evaluated. The blood samples will be evaluated for C-reactive protein and markers of insulin resistance (fasting glucose, insulin). All participants will be evaluated at baseline (T0) and after a 16-week intervention (T1). In addition to these time points, HRV will be measured during every exercise session for participants in exercise groups. Generalized estimating equations will be used to determine whether baseline BMI is the key factor influencing the effects of AE.
Relevance to clinical practice: The findings will serve as a reference for clinical professionals to promote exercise among the general population for improving HRV.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 51
- are aged between 40 and 64 years.
- had inactive habit (<3 days of physical activity per week and <30 minutes per session).
- can communicate in Mandarin or Taiwanese.
- underlying conditions, such as stroke, acute coronary artery diseases, handicap, pregnancy, and unstable hypertension, that may present risks for exercise training.
- smoking or alcohol abuse.
- currently being on a diet, and (d) lifestyles that may affect HRV and inflammatory biomarkers (e.g., shift work or habit of staying up late).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description aerobic exercise(AE), normal weight aerobic exercise(AE) 3 times a week, normal weight aerobic exercise(AE) , overweight/obese aerobic exercise(AE) 3 times a week, overweight/obese
- Primary Outcome Measures
Name Time Method Visceral fat two times (change from baseline to the end of 16-week) will use body composition analyzer
insulin resistance two times (change from baseline to the end of 16-week) μIU/mL
Heart rate variability two times and each session of exercise (change from baseline to the end of 16-week) will use heart rate variability analyzer
body weight two times (change from baseline to the end of 16-week) weight in Kilogram
Waist-to-height ratio two times (change from baseline to the end of 16-week) Waist-to-height ratio
fasting glucose two times (change from baseline to the end of 16-week) mg/dL
Waist-to-hip ratio two times (change from baseline to the end of 16-week) Waist-to-hip ratio
C-reactive protein two times (change from baseline to the end of 16-week) mg/L
BMI two times (change from baseline to the end of 16-week) weight and height will be combined to report BMI in kg/m\^2
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Yu-Hsuan Chang
🇨🇳Tainan, Taiwan