Fertility and Ovarian Reserve Function in the Patient With Inflammatory Bowel - a Cross-sectional Survey and Case Control Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- The E2 of IBD patients is lower than that of healthy women
研究概览
简要总结
ECCO consensus, the fertility would decline in activity inflammatory bowel disease(IBD), because of anus lesions and pelvic abscess, or who underwent surgery, especially in patients with ileal pouch anal anastomosis (IPAA) storage.The study on fertility in inflammatory bowel disease were almost epidemiological investigation, the lack of objective evaluation of fertility, and controversial.This study will explore the fertility, ovarian reserve function and the pregnancy outcomes in patients with IBD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 17 Years 至 40 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Inflammatory bowel disease
- •17-40 years old
排除标准
- •in pregnancy or lactation
- •a drug that has been or is being used known to affect ovarian function, such as cyclophosphamide
- •reproductive system diseases unrelated to disease or treatment of inflammatory bowel disease, such as hysterectomy, pelvic radiotherapy after surgery, after ovariectomy, polycystic ovary syndrome, endometriosis, ovarian granulosa cell tumor
- •other endocrine diseases, such as prolactin, hyperthyroidism, lead to endocrine disorders;
- •malignant tumor
研究组 & 干预措施
healthy control
17-40 years old , female, without any gynecological disease
干预措施: Follicle-Stimulating Hormone (Other)
IBD patients
IBD patients, 17-40 years old, female
干预措施: Anti Mueller hormone (Other)
IBD patients
IBD patients, 17-40 years old, female
干预措施: Estrogen (Other)
IBD patients
IBD patients, 17-40 years old, female
干预措施: Antral alveolar cell count (Other)
healthy control
17-40 years old , female, without any gynecological disease
干预措施: Anti Mueller hormone (Other)
healthy control
17-40 years old , female, without any gynecological disease
干预措施: Estrogen (Other)
healthy control
17-40 years old , female, without any gynecological disease
干预措施: Antral alveolar cell count (Other)
IBD patients
IBD patients, 17-40 years old, female
干预措施: Follicle-Stimulating Hormone (Other)
结局指标
主要结局
The E2 of IBD patients is lower than that of healthy women
时间窗: 1 month
E2 is used to assess ovarian reserve function
The FSH of IBD patients is lower than that of healthy women
时间窗: 1 month
FSH is used to assess ovarian reserve function
The AFC of IBD patients is lower than that of healthy women
时间窗: 1 month
AFC is used to assess ovarian reserve function
The AMH of IBD patients is lower than that of healthy women
时间窗: 1 month
AMH is used to assess ovarian reserve function
次要结局
未报告次要终点
研究者
pengxiang
Attending doctor
Sixth Affiliated Hospital, Sun Yat-sen University