APPLICATION OF MRI FLOW STUDY IN PATIENTS WITH EITHER INCREASED OR DECREASED PRESSURE OF FLUID INSIDE THE CRANIAL CAVITY

Not Applicable

Completed

• Conditions: Health Condition 1: G910- Communicating hydrocephalusHealth Condition 2: G10-G14- Systemic atrophies primarily affecting the central nervous system

• Registration Number: CTRI/2018/10/015933
• Lead Sponsor: DEPARTMENT OF RADIODIAGNOSIS

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2019-09-20
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

CONTROLS: Volunteers referred for MRI for indications other than conditions causing increased or decreased intracranial pressures with age ranging from 18 to 80 years.

Participants are recruited after the routine MRI/CT study shows suspicion or indeterminate results (i.e. discrepancy with clinical findings) and are then taken up for few special flow MRI sequences which require extra 12 minutes (apart from the routine protocol).

The informed consent is taken at the MRI console.

Enrolment in NPH group: Patients with clinical and imaging features of NPH and/or a positive tap test.

Enrolment in diffuse cerebral atrophy group: Patients with imaging features typical of cerebral atrophy with no clinical or imaging features suggestive of NPH.

Enrolment in hydrocephalus group: Patients with hydrocephalus caused by periaqueductal or fourth ventricular obstruction as seen on conventional CT/MR.

Enrolment in benign intracranial hypertension group: Patients presenting only with papilledema with normal MR imaging.

Enrolment of patients with clinical conditions resulting in CSF hypovolemia:

True hypovolemic state

CSF shunt over drainage

Traumatic CSF leaks

Iatrogenic CSF leaks (post dural puncture/post-surgical leaks)

Spontaneous CSF leaks.

With routine MRI or clinical follow-up suggesting CSF hypovolemia.

Exclusion Criteria

1)Individuals with metallic implants in-situ.

2)Individuals with claustrophobia

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cut-off values for absolute stroke volume, net aqueductal stroke volume, mean velocity, maximum velocity, minimum velocity will be obtained for the sample population and the variations in these parameters in various disease states from the controls will be assessed concluding the extent of CSF hydrodynamics alterations.Timepoint: ZERO

Secondary Outcome Measures

Name	Time	Method
To establish importance of MRI CSF flow study as an adjunct to conventional MRI in diagnosis of cases with increased and decreased intracranial pressure.Timepoint: ZERO