Role of Anterior Segment Optical Coherence Tomography in Infectious Keratitis

Completed

• Conditions: Infective Keratitis
• Interventions: Other: Optical coherence tomography

• Registration Number: NCT04969640
• Lead Sponsor: Minia University

Brief Summary

To evaluate the role of anterior segment optical coherence tomography in follow up of infectious keratitis and assessment of response to treatment.

Detailed Description

50 patients with proven infectious keratitis clinically will be included in the study.

The following will be performed for all patients in initial visit and follow up:

* Slit lamp examination and photography.

* Visual acuity assessment.

* Anterior segment optical coherence tomography.

1. The central corneal thickness (CCT) (extracted from pachymetry map),

2. Minimal corneal thickness (MCT) (extracted from pachymetry map)

3. Corneal thickness at the site of the lesion (CTL) (extracted from pachymetry map or the sum of STL+ CETL)

4. Stromal thickness at the center of the lesion (STL) stromal lesion (extracted from stromal map)

5. Corneal epithelial thickness over the stromal lesion (CETL) at the center of the lesion (extracted from epithelial map)

Study Timeline

• Study First Submitted: 2021-06-25
• Study Start: 2021-07-01
• Study First Submitted QC: 2021-07-16
• Study First Posted: 2021-07-21
• Primary Completion: 2021-12-31
• Study Completion: 2021-12-31
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-28
• Last Update Posted: 2023-03-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 23

Inclusion Criteria

• Any case with infectious keratitis (any age) either received medical treatment or not, attending to our department will be included in the study.

Exclusion Criteria

• Cases with healed infectious keratitis.
• Cases presented from the start with severe corneal affection and melting.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
infective keratitis	Optical coherence tomography	50 cases with infectious keratitis (any age) either received medical treatment or not, attending to our department will be included in the study.

Primary Outcome Measures

Name	Time	Method
width of lesion on optical coherence tomography	1 month	width of infiltration in microns
criteria of lesion on optical coherence tomography	1 month	Localiztion, depth of infiltration area in microns

Trial Locations

Locations (1)

Faculty of Medicine; 🇪🇬 Minya, Egypt