Tolerance of Myocardium to Ischemia Injury

Not Applicable

Completed

• Conditions: Reperfusion Injury; Myocardial Ischemia

• Registration Number: NCT02812901
• Lead Sponsor: University Hospital, Lille

Brief Summary

This study aims to understand the impact of time-of-the day on human myocardial tolerance to ischemia-reperfusion by exploring atrial myocardium biopsied during cardiac surgery. Patients scheduled for non-urgent cardiac surgery (coronary artery by-pas graft and/or aortic valve replacement) will be assigned to a morning or an afternoon cardiac surgery based on randomization. Myocardial biopsies will be explored in ex vivo conditions mimicking ischemia-reperfusion.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01
• Study First Submitted: 2016-06-22
• Study First Submitted QC: 2016-06-23
• Study First Posted: 2016-06-24
• Primary Completion: 2017-07
• Study Completion: 2017-07
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-29
• Last Update Posted: 2017-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

• Patient scheduled for coronary artery bypass graft surgery and/or aortic valve replacement with extra-corporeal circulation
• Patient in sinus rhythm at the time of surgery
• Patient older than 18
• Patient able to understand the information and consent forms

Exclusion Criteria

• Medical history of type 2 diabetes, atrial fibrillation or use of class III anti-arhythmic drug
• left ventricle ejection fraction < 40%
• Pregnancy
• Patient in emergency condition

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
ischemia reperfusion injury in ex vivo conditions	the day of the myocardial biopsy	measurement of hs troponin T released by the myocardium samples in the superfusion solution after ex vivo conditions mimicking ischemia-reperfusion

Trial Locations

Locations (1)

Lille University Hospital; 🇫🇷 Lille, France