Different Regulation of Immune Cells in Patients With Preeclampsia

• Conditions: Preeclampsia; Pregnancy
• Interventions: Procedure: Blood withdrawal

• Registration Number: NCT02691364
• Lead Sponsor: University Medical Center Groningen

Brief Summary

Adaptation of the maternal immune system to accommodate the semi-allogeneic fetus is necessary for pregnancy success. Dysregulation of this immune adaptation is implicated in reproductive disorders as infertility, recurrent miscarriage, fetal growth restriction, and preeclampsia. The mechanisms being responsible for fetal tolerance are not known. Several T cell subsets have been implicated in fetal tolerance. The effects of preeclampsia on memory cells are not known. The main objective of this study is to analyze the effect of preeclampsia on levels of immune cells.

Detailed Description

Not available

Study Timeline

• Status Verified: 2016-02
• Study First Submitted: 2016-02-22
• Study First Submitted QC: 2016-02-24
• Last Update Submitted: 2016-02-24
• Study First Posted: 2016-02-25
• Last Update Posted: 2016-02-25
• Study Start: 2016-04
• Primary Completion: 2017-05
• Study Completion: 2017-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

• healthy
• written informed consent
• 18-40 years

Exclusion Criteria

• smoking
• immune related disorders (other than preeclampsia)
• fever / illness within the last month
• infertility
• body mass index <18 or >30

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Preeclamptic	Blood withdrawal	Pregnant women with preeclampsia
Healthy	Blood withdrawal	Healthy women

Primary Outcome Measures

Name	Time	Method
Cell levels	1 year