Effects of High Intensity Interval Training in a Hyperoxic-hyperbaric Environment on Exercise Performance at Altitude
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Change in Ventilatory Threshold (VT) From Baseline to Post-training (<72 Hours)
研究概览
简要总结
This study seeks to examine the effectiveness of training while in a hyperoxic-hyperbaric environment for exercise performance at altitude. Subjects will complete a short, high-intensity interval training (HIT) program inside the hyperbaric chamber.Before and after this training phase, all subjects will be tested for maximum aerobic capacity at a simulated high altitude of 15,000ft in a hypobaric chamber, as well as for molecular markers of mitochondrial oxidative capacity in a skeletal muscle biopsy.
A group of individuals of similar characteristics completing this training program in a normoxic-normobaric environment will serve as a control.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy, recreationally active or sedentary individuals
排除标准
- •VO2max < 35 ml/kg/min - male 30 ml/kg/min - female
- •chronic cardiovascular or pulmonary diseases
- •history of pneumothorax
- •active smoker
- •pregnant women
- •non-english speaking
- •not in full mental capacity
- •sickle cell trait or disease
研究组 & 干预措施
Normoxic, Normobaric
Normoxic, normobaric, interval exercise training Six sessions of 30 min.of High-intensity interval training completed on a 3-times a week basis.
干预措施: Normoxic, normobaric, interval exercise training (Procedure)
Hyperoxic, Hyperbaric
Hyperoxic hyperbaric interval exercise training Six sessions of 30 min.of High-intensity interval training completed on a 3-times a week basis at 1.4 ATA of oxygen in a hyperbaric chamber.
干预措施: Hyperoxic hyperbaric interval exercise training (Procedure)
Hyperoxic, Hyperbaric
Hyperoxic hyperbaric interval exercise training Six sessions of 30 min.of High-intensity interval training completed on a 3-times a week basis at 1.4 ATA of oxygen in a hyperbaric chamber.
干预措施: Oxygen (Drug)
结局指标
主要结局
Change in Ventilatory Threshold (VT) From Baseline to Post-training (<72 Hours)
时间窗: Baseline and <72 hrs Post-training
Graded exercise test to exhaustion at simulated 15000 ft altitude
COX-I Gene Expression Change
时间窗: Baseline/24 hrs Post-training
Real-time PCR
Change in Maximum Aerobic Capacity (VO2max) From Baseline to Post-training (< 72 Hours )
时间窗: Baseline and <72 hrs Post-training
Graded exercise test to exhaustion at simulated 15000 ft altitude
Pgc-1a Coactivator Muscle Protein Content Change
时间窗: Baseline/24 hrs Post-training
Western analysis
Muscle Phenotype Change
时间窗: Baseline/24 hrs Post-training
Immunofluorescence microscopy using citrate synthase staining
Mitochondrial Mass Change
时间窗: Baseline/24 hrs Post-training
Immunofluorescence microscopy using citrate synthase staining
Tfam Muscle Protein Content Change
时间窗: Baseline/24 hrs Post-training
Western analysis
次要结局
未报告次要终点