Effect of Aerobic Training Versus Resistance Training on Plasma Homocystiene in Diabetic Patients

Not Applicable

Active, not recruiting

• Conditions: Diabete Type 2
• Interventions: Other: aerobic exercises; Other: resistance exercises

• Registration Number: NCT05845190
• Lead Sponsor: Egyptian Chinese University

Brief Summary

The goal of this \[clinical trial\] is to \[ compare \] in \[ diabetic male patients \]. The main question to answer is :

Will be any difference between aerobic exercises and resistance exercises in improving levels of homocysteine, cholesterol and insulin in diabetic patients?

Participants will take their medications and group of them do aerobic exercises and another group do resistance training

Detailed Description

40 male diabetic patients diagnosed by type 2 diabetes mellites to evaluate therapeutics outcomes of aerobic exercises versus resistance exercises as a treatment tool on homocysteine, insulin and cholesterol levels in diabetic patients.

The patients will be randomly assigned to two equal (in number) groups:

Group (A) Twenty male patients will receive moderate intensity aerobic exercises in a form of supervised treadmill walking for 30-45 mins performed 3 times/ week for 12 weeks.

Group (B) Twenty male patients will receive resistance training program comprised 30-45 min performed 3 times /week for 12 weeks.

Study Timeline

• Study Start: 2022-04-04
• Status Verified: 2023-04
• Study First Submitted: 2023-04-26
• Study First Submitted QC: 2023-04-26
• Last Update Submitted: 2023-04-26
• Study First Posted: 2023-05-06
• Last Update Posted: 2023-05-06
• Primary Completion: 2023-05-15
• Study Completion: 2023-05-15

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

• 1- Their ages will range from 40 -55 years 2- Their body mass indexes will range between (25 to 35 Kg / m²). 3-All patients are diagnosed with type 2 diabetes mellites.

• Diagnostic criteria for type 2 diabetes were: 1) a fasting plasma glucose concentration of 7.0 mmol·L-1 or higher or 2) a plasma glucose concentration of 11.1 mmol·L-1 or higher two hours after an oral glucose challenge. (Punthakee et al.,2018).

• All subjects took oral hypoglycemic drugs but none of them were being treated with insulin when enrolled.

  4- All patients are medically and psychologically stable

Exclusion Criteria

1. Patients with uncontrolled blood glucose level
2. Patients with unstable cardiovascular conditions (those with a known history of uncontrolled hypertension, ischemic attacks, stroke, congestive heart failure, currently on anticoagulation therapy) were excluded from this study.
3. Patients with severe pulmonary disease (with restrictive lung disease or with obstructive lung disease).
4. Patients with musculoskeletal disorders (Diagnosed with severe osteoporosis or severe osteoarthritis).
5. Patients with BMI > 35 will be excluded from the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
aerobic exercises group (group A )	aerobic exercises	20 male patients with diabetes mellites Attended the program of walking on treadmill for 12 weeks according to the following parameters. Exercise prescription: Intensity: started by 60-75% of target heart rate according to each patient response. Duration: Each session consisted of five minutes warming up firstly then 25-30 minutes time of session ended by five minutes cool down exercises Frequency: Three times / week (day after day) for 12 weeks
resistance exercises group (group B)	resistance exercises	20 male patients with diabetes mellites will participate in resistance training exercises 30-45 mins. The subject will warm up and cool down for at least five to seven minutes each, (before and after exercise) with initial load of 60% of 1 repetition maximum. This program consists of 3 sets of 8 to 12 repetitions, then increasing load when subject was able to complete 12 repetitions. A rest period of 1.5 min was established between each set. Mode: 4 upper body exercises (bench press, seated row, shoulder press, and pull down), 3 leg exercises (leg press, extension, and flexion), abdominal crunches and back extensions. with the individualized workloads at 60% of 1RM. Duration: 30 min-45 min (total session). Frequency: Three times / week (day after day). Intensity: increased load was established when subject was able to complete 12 repetitions.

Primary Outcome Measures

Name	Time	Method
homocystiene	12 weeks of training	Homocysteine was measured with an enzyme linked immunosorbent (ELISA) method. The upper limit of normal is 15 μmol/l

Secondary Outcome Measures

Name	Time	Method
insulin	12 weeks of training	normal value \<25 mlu/L fasting
cholestrol	12 weeks of trianing	Desirable cholesterol levels are considered to be those below 200 mg/dL in adults

Trial Locations

Locations (1)

Egyptian Chineese University; 🇪🇬 Cairo, Gesr Elsuez, Egypt