Noninvasive Positive Pressure Ventilation Using Helium:Oxygen Versus Air:Oxygen in Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Patients Exposed to Sulfur Mustard
Phase 3
Completed
- Conditions
- BronchiolitisChronic Obstructive Pulmonary Disease
- Registration Number
- NCT00515606
- Lead Sponsor
- Baqiyatallah Medical Sciences University
- Brief Summary
to assess the effectiveness of helium:oxygen mixture adjunct with non-invasive ventilation in sulfur mustard exposed patients with acute decompensation
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- Not specified
Inclusion Criteria
- a history of previous exposure to sulfur mustard
- worsening dyspnea during the last 10 days
- respiratory rate >25/min
- arterial pH<7.35
- PaCO2 of >50 mmHg
- PaO2 of <50 mmHg
Exclusion Criteria
- recent pneumothorax (<1 month)
- severe respiratory failure or hemodynamic instability with forthcoming intubation
- FIO2 of <0.4
- impaired consciousness or absence of patient cooperation
- facial lesions precluding NIV
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method assess spirometry and hemodynamic measures after heliox or air:oxygen use
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie helium:oxygen mixture efficacy in sulfur mustard-induced acute respiratory failure?
How does noninvasive positive pressure ventilation with helium:oxygen compare to conventional air:oxygen therapy in COPD patients with sulfur mustard exposure?
Which biomarkers correlate with improved outcomes in COPD patients using helium:oxygen noninvasive ventilation post-sulfur mustard exposure?
What adverse events are associated with helium:oxygen NIPPV in sulfur mustard-exposed COPD patients and how are they managed?
Are there combination therapies or alternative gases showing better efficacy than helium:oxygen for COPD exacerbations caused by sulfur mustard?