Effect of daily sedative interruption on sleep stages in mechanically ventilated patients.

Not Applicable

• Conditions: Mechanically ventilated patient

• Registration Number: JPRN-UMIN000002362
• Lead Sponsor: Emergency and Critical Care Medicine Tokushima University Hospital

Brief Summary

Patients in daily sedative interruption group showed increasing amount of stage 3 and 4 non rapid eye movement (NREM) sleep (6 min vs. 0 min, P = 0.04) and rapid eye movement (REM) sleep (54 min vs. 0 min, P = 0.02) compared with patients in continuous sedation group. In continuous sedation group, total sleep time during nighttime was longer (8.7 h vs. 7.3 h, P = 0.047) and frequency of arousal was lower (2.2 event/h vs. 4.4 event/h, P = 0.03) than those in daily sedative interruption group.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-08-24
• Study Completion: 2011-01-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Not provided

Exclusion Criteria

Patients who were the psychiatric illness, anoxic brain injury, suspected encephalopathy (drug overdose, hepatic failure), seizure disorder, and severe hemodynamic instability in whom systolic blood pressure was < 90mmHg despite vasopressor support

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
sleep characteristics in night time period.

Secondary Outcome Measures

Name	Time	Method
dosage of sedatives and analgesics in nighttime period