Study R-FACT Risk factors for alloimmunization against red blood cell transfusions: a case cohort study

Recruiting

• Conditions: red blood cell immunization; transfusion related hemolysis; 10018911

• Registration Number: NL-OMON44808
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 1500

Inclusion Criteria

- Patients for the first time diagnosed with transfusion dependent red blood cell alloantibodies (=patients who received transfusions before detection of alloantibodies).
- Patients who have been transfused, yet did not form red cell alloantibodies afterwards

Exclusion Criteria

- Age below 18 years
- Patients with transfusions prior to the start of study inclusion period.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Our case-control study will quantify and characterize clinical risk factors of<br /><br>patients and conditions for transfusion associated alloimmunisation. Patients<br /><br>will be given a questionnaire to assess environmental and life style risk<br /><br>factors.<br /><br>Blood sampling (upon informed consent) and buccal mucosal swabs will be carried<br /><br>out to determine genetic variation of immunization against red blood cell<br /><br>antigens.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-na-</p><br>