Effect of Aggressive vs. Lenient Blood Pressure Control in Patients with Ventricular Tachycardia (VT) on Future VT and Death

Sachin Nayyar0 个研究点目标入组 120 人开始时间: 2020年7月27日最近更新: 2024年1月29日

适应症

试验速览

暂无简介。

•1. Age 18-year to 80-years.
•2. Heart failure due to ischemic or non-ischemic etiology of more than 3 months duration.
•3. Left ventricular ejection fraction <40%.
•4. History of spontaneous sustained VT.
•5. Have an implantable cardioverter defibrillator (ICD) or consent to have one.
•6. NYHA Class 1 -3.

•1.VT related hospitalization within the last 3 weeks.
•2.VT ablation in last 3 months.
•3.Heart failure NYHA Class 4 or heart failure hospitalization within the last 3 weeks.
•4.Resting systolic BP < 90mmHg at lowest doses of heart failure medication.
•5.History of symptomatic systolic BP drop on standing.
•6.Exercise induced systolic BP > 180mmHg or <90mmHg.
•7.Known secondary cause of hypertension.
•8.eGFR less than 30ml/min.
•9.Intolerance to beta-blocker (equivalent to Metoprolol 12.5mg BD) (due to worsening of hypotension or heart failure).
•10.Left ventricular ejection fraction <10%.
•11.Suspected tachy-cardiomyopathy (arrhythmia as cause of heart failure).
•12.Acute coronary event or stroke within the last 3 months.
•13.Coronary revascularization within the last 3 months.
•14.Expected survival less than 3 years due to terminal non-cardiac illness.
•15.Severe pulmonary artery hypertension.
•16.Large pericardial effusion.
•17.Severe peripheral vascular disease or aortic aneurysm.
•18.Non-compliance to medication.
•19.Active alcohol or substance abuse.
•20.Pregnancy.
•21.Morbid obesity (BMI >40).
•22.Remote residence out of reach to clinic sites.
•23.Dementia or other cognitive impairment in ability to follow the protocol.
•24.Current participation in another trial.

发起方

Sachin Nayyar