Prospective Randomized Trial of Impact of High PEEP Application Following Pulmonary Endarterectomy on Outcome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- free oxygen radicals levels
研究概览
简要总结
Investigation of the effect of intraoperative lung protection high PEEP maneuver on ischemic reperfusion injury in patients undergoing pulmonary endarterectomy.
详细描述
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease characterized by progression of thromboembolism obstructing pulmonary arteries as an organized tissue. Pulmonary thromboendarterectomy (PTE) is a treatment option for chronic thromboembolic pulmonary disease. However, PTE is associated with specific postoperative complications, such as pulmonary edema and right ventricular failure due to reperfusion injury, with a significant mortality rate of 7% to 24%. Some strategies have been proposed to reduce lung injury after PTE, such as rectification maneuvers and high PEEP. The aim of this study was to investigate the effect of intraoperative lung protection high PEEP maneuver in patients undergoing pulmonary endarterectomy for ischemic reperfusion injury.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing elective PTE operation due to CTEPH,
- •20-70 years old
排除标准
- •Patients with chronic inflammatory disease,
- •liver and renal failure,
- •heart failure (<EF: 40%),
- •intraoperative bronchial hemorrhage,
- •patients undergoing postoperative revision.
结局指标
主要结局
free oxygen radicals levels
时间窗: 48 hours
Superoxide dismutase (SOD) activity will be measured by modification of the method of Sun et al. and Protein carbonyl groups will be determined by volume modification according to Reznick and Packer method.
次要结局
- postoperatif outcome - Duration of stay in the intensive care unit and hospital stay(10 day)
研究者
mustafa emre gürcü
anesthesia and reanimation specialist
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital