Prospective Randomized Trial of Impact of High PEEP Application Following Pulmonary Endarterectomy on Outcome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Reperfusion Injury After Pulmonary Thromboendarterektomy
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- free oxygen radicals levels
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Investigation of the effect of intraoperative lung protection high PEEP maneuver on ischemic reperfusion injury in patients undergoing pulmonary endarterectomy.
Detailed Description
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease characterized by progression of thromboembolism obstructing pulmonary arteries as an organized tissue. Pulmonary thromboendarterectomy (PTE) is a treatment option for chronic thromboembolic pulmonary disease. However, PTE is associated with specific postoperative complications, such as pulmonary edema and right ventricular failure due to reperfusion injury, with a significant mortality rate of 7% to 24%. Some strategies have been proposed to reduce lung injury after PTE, such as rectification maneuvers and high PEEP. The aim of this study was to investigate the effect of intraoperative lung protection high PEEP maneuver in patients undergoing pulmonary endarterectomy for ischemic reperfusion injury.
Investigators
mustafa emre gürcü
anesthesia and reanimation specialist
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing elective PTE operation due to CTEPH,
- •20-70 years old
Exclusion Criteria
- •Patients with chronic inflammatory disease,
- •liver and renal failure,
- •heart failure (\<EF: 40%),
- •intraoperative bronchial hemorrhage,
- •patients undergoing postoperative revision.
Outcomes
Primary Outcomes
free oxygen radicals levels
Time Frame: 48 hours
Superoxide dismutase (SOD) activity will be measured by modification of the method of Sun et al. and Protein carbonyl groups will be determined by volume modification according to Reznick and Packer method.
Secondary Outcomes
- postoperatif outcome - Duration of stay in the intensive care unit and hospital stay(10 day)