Can pupil diameter changes predict individual variability of opioid sensitivity?
Not Applicable
- Conditions
- Patients undergoing laparoscopic hysterectomy
- Registration Number
- JPRN-UMIN000039582
- Lead Sponsor
- Teikyo University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Female
- Target Recruitment
- 70
Inclusion Criteria
Not provided
Exclusion Criteria
Patients receiving regional anesthesia, taking opioids, having contraindication for drugs planned to use. Patients with diabetes mellitus, psychotic and neurological diseases. Patients taking beta blocking agents, anti-cholinergic agents, and anti-psychotic drugs.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Association between the percent decrease in the pupil diameter following a small dose of fentanyl and remifentany consumption during surgery (normalized with ideal body weight and duration of anesthesia). Association between the percent decrease in pupil diameter following a small dose of fentanyl and postoperative fentanyl consumption within 24 h after surgery (normalized with body weight).
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link pupil diameter changes to opioid sensitivity in laparoscopic hysterectomy patients?
How does pupillometry compare to other predictive methods for perioperative opioid requirements in surgical patients?
Which biomarkers are most effective for predicting individual variability in opioid response during laparoscopic hysterectomy?
What are the potential adverse events associated with pupillometry-based opioid dosing strategies in gynecological surgery?
Are there alternative non-opioid analgesic approaches being evaluated alongside pupillometry in laparoscopic hysterectomy trials?