Assessment of effect of crocin on Covid-19 patients

Phase 3

Recruiting

Conditions: Covid 19.
COVID-19, virus identified
U07.1

Registration Number: IRCT20210203050233N1

Lead Sponsor: ational Institute for Medical Research Development (NIMAD)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

1.Confirmed cases of Covid-19
2.Patients admitted to hospital Covid-19 general wards
3.Being 20-60 years old, of either sex.
4.Ability to sallow oral medication.
5.Patients without immunodeficiency and gastrointestinal disorders
6.Not being pregnant/breast feeding

Exclusion Criteria

1.Being allergic to saffron/crocin
2.Inability to swallow oral medication during admission

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cell blood count (CBC). Timepoint: on days 0, 7 and 14. Method of measurement: CBC will be measured by auto analyzer. Differential cell counts will be performed in stained peripheral blood smear (Wright-Giemsa) under light microscope.;Serum C-reactive protein (CRP) level. Timepoint: on days 0, 7 and 14. Method of measurement: CRP serum level will be measured using standard ELISA kits.;TNF-a serum level. Timepoint: on days 0, 7 and 14. Method of measurement: TNF-a serum level will be measured using standard ELISA kits.;LDH serum level. Timepoint: on days 0, 7 and 14. Method of measurement: LDH serum level will be measured using standard ELISA kits.;Erythrocyte sedimentation rate (ESR). Timepoint: on days 0, 7 and 14. Method of measurement: Sedimentation Analyzer.

Secondary Outcome Measures

Name	Time	Method
A.Clinical signs and symptoms: fever, cough, dyspnea, myalgia, chill, headache, respiratory rate, weakness, chest pain, nausea, vomiting, gastro-intestinal manifestations, O2 saturation. Timepoint: On days 0 and 14. Method of measurement: Clinical signs and symptoms will be recorded using the checklist.;Lung involvement. Timepoint: On days 0 and 14. Method of measurement: Lung radiography assessment will be performed by lung high-resolution computed tomography (HRCT).