ACTRN12610000246088招募中未知
SUSTAIN For PAIN: Subcostal UltraSound guided Transversus Abdominis plane INfusions for Pain relief of Abdominal INcisions
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Patients age 18 years or over.
- •Elective or semi-elective surgery requiring a mid-line abdominal incision.
- •Planned intraoperative Transversus Abdominis Plane blocks and postoperative morphine patient controlled analgesia.
排除标准
- •Plan for epidural and/or spinal analgesia.
- •Surgeon or anaesthetist refusal to placement of catheters.
- •Inability to communicate in English due to a language barrier, cognitive deficit or intellectual disability.
- •Inability of patient to use patient controlled analgesia (PCA) pump postoperatively or to understand visual analogue pain score.
- •Patients flagged for postoperative ventilation.
- •Asthma if exacerbated by non-steroidal anti-inflammatory drugs (NSAIDs) or asthma if a patient has never taken a NSAID.
- •Acute abdomen, with clinical signs of abdominal peritonism.
- •Septicaemia involving positive bacterial blood cultures.
- •Localised infection at the site of proposed needle insertion.
- •Opioid tolerant patients, i.e. any of the following:
- •-Patient taking an average of 8 Panadeine Forte tablets per day for a greater than one week.
- •-Patients taking greater than 40 mg oxycodone per day for greater than one week.
- •-Patients receiving 20 mg morphine parenterally per day for greater than one week.
- •-Patients on a fentanyl patch of dose greater than 12.5 mcg/hour for greater than one week.
- •-Any patient receiving buprenorphine.
- •-Any patient receiving methadone.
- •-Any patient receiving naltrexone or naloxone as part of an opioid abstinence program.
- •Any history of injected or inhaled illicit drug use in the previous six months.
- •A clinical history of chronic pain, where patients may benefit from early commencement of ketamine.
- •Renal impairment with creatinine clearance less than 60 mL/min.
- •Severe hepatic impairment (Child-Pugh score greater than or equal to 10).
- •Patients with unstable or uncontrolled epilepsy.
- •Allergy or contraindication to morphine, ropivacaine, tramadol, parocoxib, sulphonamides or paracetamol.
- •Patients on ketaconazole, fluconazole, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors (SSRIs), serotonin noradradrenaline reuptake inhibitors (SNRIs), tricyclic anti-depressents, carbemazepine, quinidine, antipsychotics, zidovudine or warfarin.
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