Comparing preoperative and intraoperative ketamine infusion for pain management in lap appendicectomy
- Conditions
- Medical and Surgical,
- Registration Number
- CTRI/2023/11/059596
- Lead Sponsor
- Dr Hemaa S
- Brief Summary
Postoperative pain management impacts the well being and rehabilitation of the patient. • Tissue injury during surgery modifies the central processing pathway for pain perception. • Preventing sensitization by an analgesic administered before a painful stimuli is the basis for preemptive analgesia. • The induction and maintainance of central sensitization depends on tha activation of N-methyl-D aspartic acid receptors(NMDA). • Administration of ketamine ,an NMDA receptor antagonist prevents central sensitization to peripheral nociceptor stimulus and prevents postoperative pain. • This study aimed to compare the postoperative analgesic requirement in patients receiving ketamine before skin incision with those receiving after wound closure.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 120
- 1)Age group 18-60 years.
- 2)Patient fit under ASA 1 and 2.
- 1)Age>60 years.
- 2)ASA 3 and 4.
- 3)Patients who are contraindicated for General Anaesthesia 4)BMI>30.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the severity of postoperative pain,time for breakthrough pain,dose of postoperative analgesia needed 5th min, 10th min, 15th min, 20th min, 25thmin, 30thmin, 1st hour
- Secondary Outcome Measures
Name Time Method • To compare the intraoperative hemodynamic changes. • Incidence of nausea ,vomiting.
Trial Locations
- Locations (1)
Shri sathya sai medical college and research institute
🇮🇳Kancheepuram, TAMIL NADU, India
Shri sathya sai medical college and research institute🇮🇳Kancheepuram, TAMIL NADU, IndiaDr Hemaa SPrincipal investigator8610242653shemaa2796@gmail.com