Post-op Ketamine Study
Not Applicable
- Conditions
- Osteo Arthritis Knee
- Interventions
- Drug: Isotonic saline
- Registration Number
- NCT03865550
- Lead Sponsor
- Rothman Institute Orthopaedics
- Brief Summary
The purpose of this study is to establish the effect of sub-anesthetic dosing of ketamine with spinal anesthesia during total knee arthroplasty on post-operative pain and narcotic consumption. We hypothesize that sub-anesthetic ketamine will decrease post-operative pain and narcotic consumption and may secondarily lead to shorter lengths of stay, faster rehabilitation, improved postoperative outcomes and patient satisfaction.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Not specified
- Target Recruitment
- 75
Inclusion Criteria
- 18 - 85 years of age
- ASA I - IV
- Undergoing primary unilateral elective total knee arthroplasty with spinal anesthesia
Exclusion Criteria
- BMI over 40*
- Contraindication or allergy to opioid pain medication or ketamine*
- Daily opioid use for pain control before surgery in excess of systemic morphine equivalent to 10 mg*
- Ejection fraction (EF) less than 30%
- Creatinine clearance less than 30 mL/min*
- History of chronic liver failure
- Desire for nerve block or general anesthesia
- Any neurologic or psychiatric disorder (including bipolar disorder, post traumatic stress disorder, schizophrenia)
- Prior surgery on ipsilateral knee within the last 6 months
- Alcohol abuse
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Ketamine Ketamine Injectable Solution - Placebo Isotonic saline -
- Primary Outcome Measures
Name Time Method Pain as reported on Visual Analog Scale Up to 6 weeks post-operatively VAS pain reported 0-100mm
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Rothman Institute
🇺🇸Philadelphia, Pennsylvania, United States
Rothman Institute🇺🇸Philadelphia, Pennsylvania, United States