Sequential Administration Of Dual Or Single Injection Of Local Anaesthetic For Continuous Infraclavicular Block-Does It Make A Difference?-A Randomized Controlled Trial
Overview
- Phase
- Phase 3
- Status
- Not yet recruiting
- Sponsor
- Christian medical college
- Enrollment
- 174
- Locations
- 1
- Primary Endpoint
- onset of sensory blockade
Overview
Brief Summary
Local anaesthetic drugs are classified according to the duration of action as short, intermediate and long-acting drugs. Combining different classes of local anaesthetic drugs for peripheral nerve blocks has faster onset and prolonged duration of action. The purpose of this double blinded randomized controlled study is to compare onset and duration of action between sequential administration of one drug and a mixture of two different drugs , in terms of onset and duration, however, the same pharmacological groups of local anaesthetic drugs, for ultrasound guided infraclavicular approach with to brachial plexus block. An infraclavicular approach to the brachial plexus block can be used for surgical procedures below the mid humerus. It has gained popularity because of its ease of performance and the ability to simultaneously anaesthetize the axillary, musculocutaneous, median, radial and ulnar nerves. The block can be done with minimal risk of pneumothorax and other complications such as block of the phrenic nerve or stellate ganglion. An infraclavicular approach to brachial plexus block provides sufficient anaesthetic and analgesic effect for below-elbow and hand surgeries. Infraclavicular approach is not only advantageous for inserting a perineural catheter, but also has a short procedure time compared to other approaches including supraclavicular and axillary approaches especially using ultrasound guidance
Group A- will receive 10ml 0.5% Ropivacine+10 ml 0.5% Ropivacaine
Group B- will receive 10ml 1% Lignocaine+10 ml 0.5% Ropivacaine
Post procedure the onset of block is assessed by recording the sensory and motor blockade by time to complete loss of sensation and complete loss of motor power, need for intraoperative surgical anaesthesia and analgesia, is recorded and duration of block is assessed by time to rescue analgesia.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Participant and Investigator Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 75.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients with ASA I, II, III undergoing elective below-elbow and hand surgery aged between 18-75years Either sex.
Exclusion Criteria
- •patient with significant neurological, psychiatric, or neuromuscular disease suspected coagulopathy morbid obesity chronic renal failure cardiopulmonary compromise cerebral vascular disease local infection at the site of the infraclavicular block pregnant women and children.
Outcomes
Primary Outcomes
onset of sensory blockade
Time Frame: sensory onset is assessed in minutes every 30 seconds until achieved | motor onset is assessed in minutes every 5 minutes until achieved | duration of sensory and motor blockade is assessed every 2 hours till 12 hours and every 4 hours till 24 hours
onset of motor blockade
Time Frame: sensory onset is assessed in minutes every 30 seconds until achieved | motor onset is assessed in minutes every 5 minutes until achieved | duration of sensory and motor blockade is assessed every 2 hours till 12 hours and every 4 hours till 24 hours
duration of sensory blockade
Time Frame: sensory onset is assessed in minutes every 30 seconds until achieved | motor onset is assessed in minutes every 5 minutes until achieved | duration of sensory and motor blockade is assessed every 2 hours till 12 hours and every 4 hours till 24 hours
duration of motor blockade
Time Frame: sensory onset is assessed in minutes every 30 seconds until achieved | motor onset is assessed in minutes every 5 minutes until achieved | duration of sensory and motor blockade is assessed every 2 hours till 12 hours and every 4 hours till 24 hours
Secondary Outcomes
- intraoperative use of analgesics & complications(baseline)
Investigators
Kousalya G
Christian Medical College,Vellore