A clinical trial to compare the effects of 3 drugs - Dexmeditomedine, Ketamine and Preservative free lignocaine in reducing the pain caused by injection of propofol
Phase 3
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/12/060528
- Lead Sponsor
- Dr Sanju Ashokkumar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patients who are willing to participate in the study
2. Patients undergoing surgeries that require general anaesthesia with propofol as
induction agent
3. Age group of 18-60 of either sex
4. American society of anaesthesiologist (ASA) physical status I and II
Exclusion Criteria
1.History of drug allergy
2.Patients who dont fit in the age/ ASA criteria
3.History of psychiatric disorder
4.History of seizure disorder
5.History of substance abuse
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the efficacy of intravenous dexmeditomedine ,ketamine and preservative free lignocaine in reducing the Intensity of pain upon injection of propofol graded on a four point scale (0-3) <br/ ><br> <br/ ><br>None (0) - No response to questioning <br/ ><br>Mild (1) - Pain reporting in response to questioning only <br/ ><br>Moderate (2) - Pain reporting in response to questioning and or pain reported spontaneously without questioning <br/ ><br>Severe (3) - Strong vocal response accompanied by facial grimace, arm withdrawals or tearsTimepoint: 0 seconds, 30 seconds and 60 seconds
- Secondary Outcome Measures
Name Time Method The hemodynamic variability in patients upon injecting these study agents.Timepoint: 0 seconds and 1 minute