Curcuminoid supplementation on type 2 diabetes

Not Applicable

Completed

• Conditions: Type 2 diabetes; Nutritional, Metabolic, Endocrine; Diabetes

• Registration Number: ISRCTN85826075
• Lead Sponsor: Public Health College - Harbin Medical University (China)

Brief Summary

2014 Results article in https://pubmed.ncbi.nlm.nih.gov/25374024/ (added 16/05/2022)

Detailed Description

Not available

Study Timeline

• Study Completion: 2010-01-10
• Study Start: 2010-10-25
• Last Update Posted: 30 May 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Aged 18 - 65 years, both male and female
2. Type 2 diabetes with fasting blood glucose greater than or equal to 7.0 mmol/L or postprandial blood glucose greater than or equal to 11.1 mmol/L
3. Current optimal therapeutic regimens lasting for at least 6 months

Exclusion Criteria

1. A history of type 1 diabetes, malignancies, thyroid or any other endocrine diseases likely to interfere with the study
2. Diabetic ketosis acidosis and infection in recent 3 months
3. Pregnancy or breastfeeding
4. Information incompleted or unwillingness to attempt to comply with the intervention

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. The effects of curcuminoids on glucose metabolism: fasting glucose and insulin, 2-hour post prandial glucose , HOMA-IR and HbA1c(%)<br> 2. The effects of curcuminoids on lipis metabolism:<br> 2.1. Serum cholesterol, triacylglycerol, HDL-C, LDL-C, Apo A-I and Apo B<br> 2.2. Serum LPL and AFABP<br> 2.3. Serum FFA profile<br> 2.4. Severity of fatty liver<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. Baseline characteristics: age, gender, BMI, waist circumference, waist-to-hip ratio, diabetes duration, blood pressure, drug treatment, cigarette use and physical activity level<br> 2. Daily intake of nutrients by the subjects at baseline and after 3-month intervention<br> 3. Blood biochemistry characteristics of the subjects at baseline and after 3-month intervention: red blood cell, white blood cell, hemoglobin, total protein, albumin, urea nitrogen, creatinine, alanine transaminase and aspartate transminase<br>