CTIS2024-511601-34-00
Recruiting
Phase 1
Post-Operative Atrial Fibrillation after Surgical Aortic Valve Replacementand the influence of HMG-CoA reductase inhibitors - STARC210421
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Patients undergoing surgical aortic valve replacement.
- Sponsor
- Odense University Hospital
- Enrollment
- 366
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Trial 1: Patients undergoing elective solitary SAVR with bioprosthesis; Patients who are in sinus rhythm and not taking any anti\-arrhythmic medication; other than beta\-adrenergic blocking agents; at the time of surgery; No prior use of statin the last 3 months and at least 7 days prior to the time of surgery Age \>60 years; Willingness and provision of informed consent to be randomized. Trial 2: Patients undergoing elective solitary SAVR with bioprosthesis; Patients who are in sinus rhythm and not taking any anti\-arrhythmic medication other than beta\-adrenergic blocking agents, at the time of surgery; In treatment with statin in the past 3 months and of at least 7 days Age \>60 years; Willingness and provision of informed consent to be randomized.
Exclusion Criteria
- •Prior history of atrial fibrillation; Prior history of cardiac surgery; Known adverse reaction to statin; Hepatic dysfunction (Alanin\-aminotransferase more than twice the upper limit); Creatinine \>200 µmol/L; Known intolerance to statins or history of muscle toxicity with statins.
Outcomes
Primary Outcomes
Not specified
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