NCT07786467招募中不适用
Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations
Lake Erie College of Osteopathic Medicine1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2026年9月1日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Hemagglutinin inhibition assay
研究概览
简要总结
The investigators are studying if a specific osteopathic manipulative treatment protocol can improve the immune response (antibody titers) to seasonal influenza vaccination in vulnerable populations, including patients with advanced age and/or adiposity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Willing to receive OMT
- •Willing to receive influenza vaccine
- •Older than 18 years of age
排除标准
- •Younger than 18 years of age
- •Pregnancy or lactation
- •Unwilling to receive the influenza vaccine
- •Unwilling to receive OMT
- •Open wounds
- •Bone fractures
- •Moderate to severe osteoporosis
- •Severe COPD
- •Current/active infections
- •Mononucleosis infection within past 6 months
- •Liver cirrhosis
- •Cancer or metastatic disease
- •History of DVT, PE, or blood clotting disorder
- •Individuals taking blood thinning medications, except aspirin
- •Having a pacemaker or other thoracic medical devices
研究组 & 干预措施
No intervention
Sham Comparator
No intervention pre- or post-influenza vaccination.
干预措施: Sham (Other)
Complete lymphatic pumping
Experimental
Multiple sites of OMT to occur post-influenza vaccination.
干预措施: Osteopathic manipulation (Other)
Thoracic pump only
Active Comparator
Only thoracic inlet myofascial release
干预措施: Osteopathic Manipulation (Other)
结局指标
主要结局
Hemagglutinin inhibition assay
时间窗: baseline and 4 weeks post vaccination
Hemagglutinin inhibition assay assess the antibody titers in patient's blood.
次要结局
未报告次要终点
研究者
David Duriancik
Associate Professor
Lake Erie College of Osteopathic Medicine
研究点 (1)
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