Clinical Significance of Computer Aided Image Analysis in Treatment Response Evaluation of Lung Cancer

• Conditions: Lung Cancer

• Registration Number: NCT03954847
• Lead Sponsor: Wuhan Union Hospital, China

Brief Summary

The investigators will evaluate the utility of computer aided image analysis in lung cancer with the aim of predicting treatment response and prognosis.

Detailed Description

Tumor biological behavior is the fundamental cause of heterogeneous prognosis. The features found on medical images are also reflections of the tumor biological behavior. However, the limitations in spatial and intensity resolution of the naked eye are two inevitable shortcomings of image interpretation by naked eyes, resulting in subjective and limited analyses of images. Computer aided image analyses such as radiomic analysis and machine learning methods are emerging as promising image interpretation methods. The natural advantage of the unlimited spatial and intensity resolution of computers can overcome the shortcomings of visual inspection with the naked eye. Moreover, the massive computing power of computer is also far greater than that of humans. This study will focus on the application of computer aided analysis in predicting treatment response and prognosis in lung cancer.

Study Timeline

• Study Start: 2012-01-01
• Status Verified: 2019-05
• Study First Submitted: 2019-05-16
• Study First Submitted QC: 2019-05-16
• Last Update Submitted: 2019-05-16
• Study First Posted: 2019-05-17
• Last Update Posted: 2019-05-17
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

1. Patients >= 18 years old
2. Pathological diagnosis of NSCLC between 2012 and 2019;
3. PET/CT or CT examination before any cancer-specific treatment;

Exclusion Criteria

1. A time interval between treatment and image examination greater than 1 month;
2. A history of other malignancies

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall survival	2012-2021	The interval between the date of diagnosis and death

Secondary Outcome Measures

Name	Time	Method
Progression free survival	2012-2021	The interval between the date of treatment initiation and disease progression

Trial Locations

Locations (1)

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; 🇨🇳 Wuhan, Hubei, China