A Study to Assess Regional Cerebral Blood Flow as an Alzheimer's Disease Biomarker Compared to Positron Emission Tomography in Patients With Mild-to-Moderate Alzheimer's Disease and Cognitively Normal Elderly Subjects (Study MK-0000-068)(COMPLETED)
- Conditions
- Alzheimer's Disease
- Interventions
- Other: MRIOther: FDG-PET
- Registration Number
- NCT00757939
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Brief Summary
The aim of the study is to determine if regional cerebral blood flow, measured by dynamic arterial spin labeling (dASL), can be a biomarker for stage of Alzheimer's disease. The study is designed to be conducted in 2 parts in participants with mild to moderate Alzheimer's disease, and participants with normal cognition. Various imaging studies will be done using magnetic resonance imaging (MRI) and positron emission tomography (PET) along with neurocognitive assessments. Participants who meet the study-entry criteria will have up to 8 study visits. Repeat imaging studies may be required if the initial data are incomplete or un-interpretable. The maximum number of PET scans during the study will be limited to four.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
The prospective participant must meet, at least, all of the criteria below (among others determined by the study staff) to be eligible for study participation.
The participant:
- Has mild-to-moderate Alzheimer's Disease (AD), OR is considered cognitively normal;
- Has been on stable doses of any regularly used medications for 4 weeks prior to study start;
- Must have been on a stable dose for 12 weeks prior to study start, of any medications taken for AD.
If the prospective participant meets any of the criteria below (among others determined by the study staff) they will NOT be eligible for study participation.
The participant:
- Is living in a nursing home or skilled nursing facility;
- Has severe AD;
- Cannot undergo MRI;
- Cannot undergo PET scans;
- Has a history of neurological or neurodegenerative disorders, other than AD within 2 years prior to study start;
- Has taken Tacrine or anti-parkinsonian medications within 3 months of study start;
- Has taken corticosteroids, blood thinners, narcotic analgesics, benzodiazepines, or certain antihistamines within 1 month of study start;
- Initiates, discontinues, or changes the dose of any AD treatment during the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description AD Participants MRI Participants with a diagnosis of mild-to-moderate AD AD Participants FDG-PET Participants with a diagnosis of mild-to-moderate AD Cognitively Normal Elderly Participants MRI Elderly participants with no cognitive impairment Cognitively Normal Elderly Participants FDG-PET Elderly participants with no cognitive impairment
- Primary Outcome Measures
Name Time Method Regional cerebral blood flow, as measured by dASL. 1 week, 6 and 12 months Part I: regional cerebral blood flow, measured by dASL at Baseline and 1 week in AD participants and cognitively normal controls. Part II: regional cerebral blood flow, measured at 6 months and 12 months in AD participants and normal control participants.
- Secondary Outcome Measures
Name Time Method Rate of cerebral glucose consumption, MRglc, as measured by fludeoxyglucose-PET (FDG-PET) 12 months Regional cerebral rate of glucose consumption, MRglc, as assessed by FDG-PET will be measured at Baseline in (Part I) and at 12 months in (Part II), in AD participants and normal control participants.
Resting state functional MRI blood-oxygen-level-dependent (fMRI BOLD) response 1 week, 6 and 12 months The resting state fMRI BOLD (blood-oxygen-level-dependent) signal will be evaluated for 'Goodness-of-Fit' to the default mode network at Baseline, 1 week, and 6 and 12 months in AD participants and normal control participants.