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Clinical Trials/NCT04622930
NCT04622930
Withdrawn
Not Applicable

Smartphone Cognitive Behavioral Therapy for Social Anxiety Disorder: A Randomized, Waitlist-control Trial

Massachusetts General Hospital1 site in 1 countrySeptember 1, 2023

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Social Anxiety Disorder
Sponsor
Massachusetts General Hospital
Locations
1
Primary Endpoint
Difference in SAD severity (LSAS) at the end of treatment/waitlist period.
Status
Withdrawn
Last Updated
11 months ago

Overview

Brief Summary

The investigators are testing the efficacy of Smartphone-delivered cognitive behavioral therapy (CBT) treatment for social anxiety disorder (SAD). The investigators hypothesize that participants receiving app-CBT will have greater reduction in LSAS scores than those in the waitlist condition at treatment endpoint (week 12).

Detailed Description

The primary aims of this study are to test the efficacy of a Smartphone-based CBT treatment for adults with SAD recruited nationally. Eligible subjects (N=80) will be randomly assigned to 12 weeks of Smartphone-delivered CBT for SAD either immediately, or after a 12-week long waiting period (50-50 chance). The investigators hypothesize that Smartphone-delivered CBT for SAD will be feasible and acceptable to individuals with SAD, and that it will lead to greater reductions in SAD symptom severity compared to the passage of time (waitlist control).

Registry
clinicaltrials.gov
Start Date
September 1, 2023
End Date
December 1, 2025
Last Updated
11 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Sabine Wilhelm, PhD

Chief of Phycology

Massachusetts General Hospital

Eligibility Criteria

Inclusion Criteria

  • At least 18 years of age
  • Current diagnosis of primary DSM-5 SAD, based on MINI
  • Currently living in the United States

Exclusion Criteria

  • Psychotropic medication changes within 2 months prior to enrollment i. Participants taking psychotropic medication must have been on a stable dose for at least 2 months prior to enrollment and not change medication during study period
  • Past participation in ≥ 4 sessions of CBT for SAD
  • Current severe substance use disorder
  • Lifetime bipolar disorder or psychosis
  • Current severe comorbid major depression, as indicated by clinical judgment and/or a QIDS-SR total score ≥ 21 \*\*\*EDIT\*\*\*
  • Acute, active suicidal ideation as indicated by clinical judgment and/or a score ≥ 2 on the suicidal ideation subscale of the C-SSRS
  • Concurrent psychological treatment
  • Does not own a supported mobile Smartphone with a data plan
  • Lack of technology literacy that would interfere with ability to engage with smartphone treatment

Outcomes

Primary Outcomes

Difference in SAD severity (LSAS) at the end of treatment/waitlist period.

Time Frame: Endpoint (week 12)

The Liebowitz Social Anxiety Scale (LSAS) is a clinician-administered measure of social anxiety symptom severity. It contains 24 social situations likely to elicit social anxiety, and items are scored on a Likert scale ranging from 0 to 3. Higher scores indicate more severe SAD symptoms. The LSAS will be used to assess change in social anxiety symptoms from baseline to endpoint.

Secondary Outcomes

  • Difference in functional impairment as measured by change in The Work and Social Adjustment Scale (WSAS) total scores from baseline to week 12.(Endpoint (week 12))
  • Difference in quality of life as assessed by change in The Quality of Life, Enjoyment, and Satisfaction Questionnaire-Short Form (QLESQ-SR) total scores from baseline to week 12.(Endpoint (week 12))
  • Difference in depression severity as assessed by change in The Center for Epidemiologic Studies Depression Scale - Revised (CESD-R) total scores from baseline to week 12.(Endpoint (week 12))

Study Sites (1)

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