Prevention of postoperative delirium with donepezil
- Conditions
- Postoperative delirium
- Registration Number
- EUCTR2006-004434-32-DE
- Lead Sponsor
- Technische Universität München, Fakultät für Medizin, Klinikum rechts der Isar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- All
- Target Recruitment
- 400
Inclusion Criteria
Patients who are 70 years and older, who are admitted for elective hip or knee joint replacement
ASA-classification I - III
Informed consent
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years)
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Evidence of delirium
Sensory impairment
Hypersensitivity to donepezilhydrochlorid (DPZ) or piperidine derivates or contraindications to the use of DPZ
bradycardia
asthma
COPD
gastric ulcer
participation in a clinical trial
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: To investigate, if perioperative treatment with donepezil reduces the incidence of postoperative delirium in patients older than 69 years with elective knee- or hip joint replacement.;Secondary Objective: To investigate, if perioperative treatment with donepezil influences<br>- severity and duration of postoperative delirium<br>- degree and duration of postoperative delirium<br>- length of hospital stay<br>- management of general anaesthesia;Primary end point(s): Incidence of postoperative delirium accotding to CAM (Confusion assessment method) criteria
- Secondary Outcome Measures
Name Time Method