Role of Terlipressin in maintaning blood pressure in a patient going into shock because of sepsis
- Conditions
- Health Condition 1: R652- Severe sepsis
- Registration Number
- CTRI/2019/10/021484
- Lead Sponsor
- Hospital Supplies AIIMS Jodhpur
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Patients older than 18 years diagnosed with septic shock during their ICU stay whose relatives give informed consent for the study will be considered for enrolment.
The following patients will be excluded from the study:
1.Patients whose relatives refuse to give consent for the study.
2.Unstable coronary artery syndrome (acute myocardial infarction during this episode of shock based on the combination of history, electrocardiogram and enzyme changes) or underlying cardiac dysfunction [cardiac index (CI) <2.2 l/min/m2]
3.Stroke or head injury.
4.Chronic renal failure on maintenance dialysis.
5.Malignancy or other irreversible disease or condition for which mortality was estimated to be very high (defined by investigator),
6.Acute mesenteric ischemia either proven or suspected
7.Raynaudâ??s phenomenon
8.Pregnancy
9.Organ transplantation.
10.Known hypersensitivity to norepinephrine or terlipressin.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To study the dose of Norepinephrine required to achieve target MAP(65-70mm of Hg) .Timepoint: After 12 hours of starting the vasopressor.
- Secondary Outcome Measures
Name Time Method 1)Duration of vasopressor requirement. <br/ ><br>2)Changes in lactate level at 12 hours after starting the infusion <br/ ><br>3)Urine output in ml per hour at 12 hours after starting of infusion <br/ ><br>4)Changes in the Sequential Organ Failure Assessment (SOFA) score after 12 hours of starting vasopressor infusion. <br/ ><br>5)Incidence of serious adverse events like digital ischemia, cardiac arrhythmias, incidence of diarrhea and upper GI bleed. <br/ ><br>Timepoint: After 12 hours of starting the vasopressor.