Using tDCS in Speech-based Stroke Rehabilitation

Not Applicable

Recruiting

• Conditions: Apraxia of Speech
• Interventions: Device: Soterix 1x1 line tDCS low-intensity stimulator; Device: Sham

• Registration Number: NCT03452202
• Lead Sponsor: NYU Langone Health

Brief Summary

The purpose of this study is to determine whether the effect of treatment for acquired speech impairment can be enhanced by combining effective behavioral treatment with non-invasive brain stimulation. Transcranial direct current stimulation (tDCS), which delivers low-intensity current to the scalp, and is a safe and well-tolerated approach that poses a non-significant risk to participants. tDCS provides low intensity neural stimulation which has been shown to facilitate motor learning in other domains of stroke rehabilitation such as arm motor learning but the potential to enhance speech motor learning has not been explored. This will be examined with a series of single-case experimental designs.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-01-16
• Study First Submitted QC: 2018-02-28
• Study First Posted: 2018-03-02
• Study Start: 2019-01-11
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-15
• Last Update Posted: 2024-10-16
• Primary Completion: 2026-10-30
• Study Completion: 2026-10-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Right-handed
• Monolingual (English)
• Single left-hemisphere CVA
• A minimum of six months post-stroke
• Clinical diagnosis of apraxia of speech
• Normal speech perception
• Passing score on the hearing screening.

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Exclusion Criteria

• Diagnosis of laryngeal voice disorder
• Dysarthria
• History of speech impairment prior to CVA
• Presence of potential tDCS risk factors: damaged skin at site of stimulation;
• Presence of electrically or magnetically activated implant (including pacemaker);
• metal in any part of their body;
• history of medication-resistant epilepsy in the family;
• past history of seizures or unexplained spells of loss of consciousness.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Active Stimulation	Soterix 1x1 line tDCS low-intensity stimulator	crossover design such that each participant receives behavioral treatment twice - once with active stimulation and once with sham stimulation - in order to evaluate differences in improvement based on treatment condition.
Sham Stimulation	Sham	crossover design such that each participant receives behavioral treatment twice - once with active stimulation and once with sham stimulation - in order to evaluate differences in improvement based on treatment condition.
Active Stimulation	Sham	crossover design such that each participant receives behavioral treatment twice - once with active stimulation and once with sham stimulation - in order to evaluate differences in improvement based on treatment condition.
Sham Stimulation	Soterix 1x1 line tDCS low-intensity stimulator	crossover design such that each participant receives behavioral treatment twice - once with active stimulation and once with sham stimulation - in order to evaluate differences in improvement based on treatment condition.

Primary Outcome Measures

Name	Time	Method
Change in accuracy in recordings from tasks from baseline to post treatment	Baseline, 6 Months	Subjects will be given speech production tasks. Recordings of tasks will be scored for accuracy to measure speech motor learning

Trial Locations

Locations (1)

New York University School of Medicine; 🇺🇸 New York, New York, United States