The Effect of Quercetin in Sarcoidosis
- Conditions
- Sarcoidosis
- Registration Number
- NCT00402623
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
The exact cause of the chronic lung disease sarcoidosis is still unknown. Consequently, a complete efficacious treatment is still not available. Earlier studies indicate an important key role for oxidative stress, i.e. an imbalance between the production of and the protection against ROS, in the etiology of sarcoidosis. Antioxidants, needed for protection against ROS, are indeed lower in sarcoidosis. Therefore, antioxidant therapy to strengthen the reduced antioxidant defense might be efficacious in sarcoidosis treatment. Since ROS are also capable of initiating and mediating inflammation, antioxidant therapy might also mitigate the elevated inflammation that occurs in sarcoidosis. The flavonoid quercetin possesses both anti-oxidative and anti-inflammatory capacities and might therefore serve as a good candidate for antioxidant therapy in sarcoidosis.
Therefore, the aim of the present study is to determine the effect of quercetin supplementation in sarcoidosis patients on markers of both oxidative stress and inflammation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 18
- clinical diagnosis of sarcoidosis with emphasize on pulmonary sarcoidosis
- no smoking
- no treatment
- clinical diagnosis (and treatment) of other diseases
- symptoms of sarcoidosis in other organs besides the lung
- use of food supplements or vitamins
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method antioxidant status after 24 hours 24 hours inflammatory status after 24 hours 24 hours
- Secondary Outcome Measures
Name Time Method plasma quercetin concentration after 24 hours 24 hours plasma malondialdehyde (MDA) levels after 24 hours 24 hours
Related Research Topics
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Trial Locations
- Locations (1)
Maastricht University
🇳🇱Maastricht, Netherlands
Maastricht University🇳🇱Maastricht, Netherlands