Effect of Local Injury on Implantation
- Conditions
- Implantation Rate
- Interventions
- Procedure: local injury
- Registration Number
- NCT00846183
- Lead Sponsor
- Yazd Research & Clinical Center for Infertility
- Brief Summary
Local injury on two sights of endometrium are performed in 60 patients in their first IVF cycle and implantation rate are compared with fresh cycles without local injury.
- Detailed Description
Low implantation rate is still a major concern in ART cycles. It has been reported that local injury to endometrium may improve endometrial receptivity and implantation rate. A total of 120 patients in first IVF cycles, who are stimulated with long protocol, are randomly divided into two groups. In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed and in the other group no interventions are done. After fresh embryo transfers, implantation and clinical pregnancy rates are compared between two groups.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 156
- Age < 35
- First IVF cycle
- Long protocol should be used for stimulation
- Day 3 FSH > 10
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description local ingury local injury In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed.
- Primary Outcome Measures
Name Time Method implantation rate 4 weeks
- Secondary Outcome Measures
Name Time Method clinical pregnancy rate 4 weeks
Trial Locations
- Locations (1)
Research and clinical center for infertility
🇮🇷Yazd, Iran, Islamic Republic of