The Cognitive Benefits of Interactive Mental and Physical Exercise for Older Adults at Risk for or With Mild Cognitive Impairment (MCI)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Mild Cognitive Impairment
- Sponsor
- Union College, New York
- Enrollment
- 111
- Locations
- 12
- Primary Endpoint
- Change from baseline in executive function at 6-months
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The purpose of this study is to clarify the benefits to brain health and thinking processes that result from different forms of exercise. This study will examine the effectiveness of cybercycling (virtual reality enhanced stationary cycling) for persons at risk for and with MCI, and compare this with the individual cognitive, behavioral, and physiological effects of physical and mental exercise alone. The Investigators hypothesis that cognitive benefit will be greatest for combined aerobic and cognitive exercise compared to physical and mental exercise alone.
Detailed Description
This is a multi-site, randomized controlled trial. Participants will be randomized into one of three conditions for six months: cybercycle-tour, cybercycle-game, or videogame alone. Comprehensive evaluations will include: neuropsychological (e.g., executive function and memory), behavioral (e.g., compliance and effort/watts), physiological (e.g., cardiorespiratory fitness), biomarker (e.g., BDNF), and an expanded neuroimaging pilot. After the six-month intervention period, participants choose whether or not to continue exercising, using any of the three conditions.
Investigators
Cay Anderson-Hanley, PhD
Associate Professor
Union College, New York
Eligibility Criteria
Inclusion Criteria
- •able to pedal recumbent stationary bicycle
- •available for regular exercise participation 3-5x/week for at least 6 months
- •physician permission to exercise
Exclusion Criteria
- •unstable heart condition or other significant cardiovascular history (e.g,. stroke)
- •meets criteria for Alzheimer's or other dementia
- •significant history of other neurological disease (e.g., seizures, Parkinson's, etc.)
- •physician denial to exercise
Outcomes
Primary Outcomes
Change from baseline in executive function at 6-months
Time Frame: Baseline and 6-months
Change in executive function from baseline at 6-months will be assessed by using a composite executive function score obtained from scores on Digit Span Backwards, Stroop, and Color Trails.
Secondary Outcomes
- Change from baseline in executive function at 3-months(Baseline and 3-months)
- Change in weight(Baseline, 3-months, 6-months, 1-year)
- Change from baseline in executive function at 1-year follow-up(Baseline and 1-year)
- Change in mood(Baseline, 3-months, 6-months, 1-year follow-up)