The Effect of Inflammation on Bone Cells

Recruiting

• Conditions: inflammatory bowel disease; 10017966; 10017322

• Registration Number: NL-OMON31917
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 55

Inclusion Criteria

1. Men and women between the age of 18 and 50 years
2. Informed consent
3a. Patients suffering from Crohn*s disease of at least 3 months duration, confirmed by
radiography, endoscopy and histology (according to the Lennard-Jones criteria ; Lennard-Jones 1989).
3b. Patients suffering from Ulcerative Colitis of at least 3 months duration, confirmed by
radiography, endoscopy and histology (according to the Lennard-Jones criteria)
4. a BMI between 18-30

Exclusion Criteria

1. Co-morbidity influencing bone metabolism
- Renal insufficiency (creatinin clearance < 40 ml/min)
- untreated hypo- / hyperthyroidism (stabily treated hypothyroidism may be included)
- Paget*s disease or other metabolic bone diseases, Cushing*s disease or hyperprolactinemia
2. Patients who have received calcitonin, bisphosphonates and strontium within 1 year
3. Use of corticosteroids current use and in the last 3 months in case of longterm use or in the last 6 weeks in case of induction therapy
4. Patients who have been treated with anti-TNF in the last 6 months
5. Use of antitrombotic agents
6. Patients who are pregnant, breast-feeding or menopausal

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>osteoblast proliferation, osteoblast differentiation, osteoclastogenesis,<br /><br>osteoclast function and bone histomorphometry</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NA</p><br>