Brain-Behavior Interactions in Tic Suppression

Completed

• Conditions: Chronic Motor Tic Disorder; Chronic Vocal Tic Disorder; Tourette's Syndrome
• Interventions: Other: Active TMS; Other: Sham TMS

• Registration Number: NCT02205918
• Lead Sponsor: University of Minnesota

Brief Summary

The purpose of this study is to examine how the brain and environment interact to influence children's ability to suppress tics using a medical technology called Transcranial Magnetic Stimulation (TMS).

Detailed Description

Objectives: This study will recruit youth with chronic tics. Chronic tics are the most common movement disorder in children. The goal of the study is to learn how the brain and environment influence children's ability to suppress tics. Specifically, we want to learn how tics are influenced by a certain part of the brain called the supplementary motor area (SMA). This part of the brain is thought to be more active in people with tics. This will be the first study to look at the relationship between SMA, tic suppression, and urges to tic.

Research Procedures: The study will take place over the course of three days within a week (about 5 hours total). The study will examine the relationship between the SMA and tic suppression using a non-invasive medical technology called Transcranial Magnetic Stimulation (TMS). Participants will have a diagnostic interview, MRI brain scan (used to find the location of the SMA), and TMS. Participants will be asked to try to suppress tics before and after TMS. The information that will be collected from participation includes information about tic symptoms, emotional and behavioral functioning, and brain activity (from MRI brain images and TMS results).

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2014-07-29
• Study First Submitted QC: 2014-07-30
• Study First Posted: 2014-08-01
• Study Start: 2017-07-01
• Primary Completion: 2019-09-01
• Study Completion: 2019-09-01
• Status Verified: 2020-07
• Last Update Submitted: 2020-07-15
• Last Update Posted: 2020-07-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Presence of motor and/or vocal tics for at least one year
• English fluency

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Exclusion Criteria

• Participants with medical conditions that are contraindicated for TMS (history of any known intracranial pathology, epilepsy or seizures, traumatic brain injury, brain tumor, stroke, implanted medical devices, current pregnancy or girls of childbearing age not using effective contraception, or any other serious medical conditions
• Left-handedness
• Previous diagnosis of psychosis, autism spectrum disorder, mental retardation, or cognitive disability
• Inability to undergo MRI
• Substance abuse or dependence within the past year
• History of ≥3 sessions of Habit Reversal Therapy or other treatment primarily comprised of tic suppression strategies
• Current suicidal intent
• Current neuroleptic medications, as these medications are known to lower seizure threshold

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Active TMS	Active TMS	Participants in this group will receive one, 30 minute session of 1hz TMS.
Sham TMS	Sham TMS	Participants in this group will receive one, 30 minute session of inactive ("sham") TMS.

Primary Outcome Measures

Name	Time	Method
Tic frequency	Day 3	Tics will be observed and counted

Secondary Outcome Measures

Name	Time	Method
Urge to tic	Day 3	The participant will be asked to give subjective ratings of premonitory urge intensity

Trial Locations

Locations (1)

University of Minnesota; 🇺🇸 Minneapolis, Minnesota, United States