Cardiac Remote Ischemic Preconditioning Before Elective Major Vascular Surgery (CRIPES)

Center for Veterans Research and Education1 site in 1 country205 target enrollmentJuly 2011

ConditionsPeripheral Arterial Disease

Overview

Phase: Phase 1
Intervention: Not specified
Conditions: Peripheral Arterial Disease
Sponsor: Center for Veterans Research and Education
Enrollment: 205
Locations: 1
Primary Endpoint: Troponin I elevation above the URL
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Vascular surgery is considered a high-risk operation with an anticipated risk of major cardiovascular complications in excess of 5%. The occurrence of a cardiovascular complication after surgery carries a long-term higher mortality risk. The main objective of this investigation is to reduce the proportion of patients having major cardiovascular complications during surgery through a clinical protocol of remote preconditioning that is safe, effective and reproducible.

Registry

clinicaltrials.gov

Start Date

July 2011

End Date

September 2015

Last Updated

10 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Center for Veterans Research and Education

Responsible Party

Principal Investigator

Santiago Garcia

Staff Cardiologist

Minneapolis Veterans Affairs Medical Center

Eligibility Criteria

Inclusion Criteria

•Eligible patients would be those undergoing elective major vascular surgery at the Minneapolis VA Medical Center for an expanding abdominal aortic aneurysm, obstructive carotid disease, and/or chronic limb ischemia during the study period. All patients must be ≥ 18 years of age and provide written informed consent.

Exclusion Criteria

•Exclusion criteria include hypertensive crisis, acute coronary syndrome in the preceding 6 weeks, severe valvular heart disease, peripheral arterial disease of the upper extremities, manifested by a systolic blood pressure difference greater than 20 mmHg, pregnant women, patients unable to understand the consent process due to mental illness, advanced malignancy with limited life expectancy (\<1 year), and hemodialysis with a fistula in the upper extremity.