Effect of Two Low Doses of Dexmedetomidine on Anesthetic Consumptions with Propofol-Based Anesthesia during Intracranial Neurosurgery: A Randomized Controlled Trial
Phase 4
- Conditions
- Patients who are scheduled for elective craniotomy from March 1, 2023 to February 28, 2026elective craniotomy
- Registration Number
- TCTR20230214001
- Lead Sponsor
- Faculty of Medicine, Change Mai University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 132
Inclusion Criteria
elective craniotomy, ASA I-III, GCS 14-15
Exclusion Criteria
1. Second- or third-degree atrioventricular (AV) block
2. Baseline heart rate (HR) less than 60/min
3. Ventricular dysfunction
4. Hepatic impairment
5. Chronic kidney disease (CKD) stage > 4
6. Pregnancy
7. Morbid obesity
8. On medication with alpha -methyldopa, clonidine
9. Need intraoperative neuromonitoring (IONM), which no need for neuromuscular blockade
10. Currently receive more than 2 kinds of antiepileptic drugs
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Intraoperative consumptions of propofol and fentanyl during 4 hours of the operation milligram of propofol and microgram of fentanyl consumption
- Secondary Outcome Measures
Name Time Method hemodynamic parameters during 4 hours of operation mmHg, beat per minute