Effects of Colchicin and Simvastatin combination therapy on the improvement of the patients with bronchectasis due to sulfur mustard gas inhalation.

Phase 3

• Conditions: Other COPD due to sulfate mustard gas.; Other chronic obstructive pulmonary disease

• Registration Number: IRCT2015060322547N1
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Male
• Target Recruitment: 50

Inclusion Criteria

Exposure to mustard gas during the Iran-Iraq war and have suffered from bronchiectasis (confirmed with CT scan). Exclusion criteria: Using Statins or Colchicin in the last 3 months of study starting time; Patients with bronchectasis without lung injury due to sulfur mustard gas; Exacerbation of symptoms in the past 4 weeks; Connective tissue disease; Sarcoidosis; Eosinophilic granuloma; Pneumoconiosis; Lymphoma; Carcinomatous; Smokers.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ung function. Timepoint: before intervention - 3 month after intervention. Method of measurement: spirometry.;Clinical signs and symptoms of the patients. Timepoint: before intervention - 3 month after intervention. Method of measurement: history and physical examinations.;Levels of IgE, IgM, IgA and IgG. Timepoint: before intervention - 3 month after intervention. Method of measurement: Immunoelectrophoresis.

Secondary Outcome Measures

Name	Time	Method
Health-related quality of life. Timepoint: before and 3 months after intervention. Method of measurement: the St George’s Respiratory Questionnaire.