Cognitive adverse effects of anti-epileptic drugs investigated using fMRI
Completed
- Conditions
- convulsionsepilepsy10039911
- Registration Number
- NL-OMON37523
- Lead Sponsor
- Epilepsiecentrum Kempenhaeghe
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 70
Inclusion Criteria
Age over 18 years old, able to give informed consent, using anti-epileptic drugs (phenytoin, topiramate, levetiracetam or lamotrigine) when investigations take place.
Exclusion Criteria
Absolute or relative contra-indications for MR scanning, unable to peform tasks in MR or unable to complete the questionnaires.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Differences between the groups on network describing MR parameters, especially<br /><br>fMRI, functional connectivity and spectroscopy; Relations between these<br /><br>parameters with their anti-epileptic drug use.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The MR parameters and anti-epileptic drug use will be correlated with<br /><br>neuropsychological test results and the results of the questionnaires.<br /><br></p><br>