Gingival Crevicular Fluid Levels of Prolactin Hormone in Obese Patients With Stage ii and Iii Periodontitis Before and After Non-surgical Periodontal Therapy (a Comparative Clinical Study)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- change in clinical attachment level
研究概览
简要总结
Obesity and periodontitis are among the most common chronic disorders affecting the world population, while Prolactin (PRL) is a neuroendocrine hormone that within the physiological range stimulates bone formation while mild to marked increase in its level induces bone resorption and inhibits bone formation.
Aim of the study: study aims to investigate prolactin (PRL) levels in gingival crevicular fluid (GCF) in obese (O) patients with and without stage II and III periodontitis (P). Further, to evaluate the effect of non-surgical periodontal therapy on these levels compared to controls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 55 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Body mass index (more than 29.9 kg/m2).
- •stage II and III periodontitis
排除标准
- •Pregnancy or lactation.
- •Any known systemic disease other than obesity
- •Previous periodontal treatment (surgical or non-surgical) in last 6 months;
- •Antibiotics in the past 3 months.
研究组 & 干预措施
Patients with peridontal disease
干预措施: Obese patients with stage II and III periodontitis and non surgical peridontal therapy (Other)
Patients without peridontal disease
干预措施: obese patients with healthy periodontium with no intervention (Other)
结局指标
主要结局
change in clinical attachment level
时间窗: Baseline and 3 months
Clinical attachment level (CAL) using a Williams probe (which manufactured in Europe from AISI 304 Stainless steel) from a fixed reference point on the crown to the base of the pocket.
change in GCF levels of prolactin hormone
时间窗: Baseline and 3 months
Gingival crevicular fluid sample will be obtained from the buccal aspects of two interproximal sites in teeth that will have the highest signs of inflammation and attachment loss
次要结局
- change in Probing depth(Baseline and 3 months)
- change in gingival index(Baseline and 3 months)
- change in plaque index(Baseline and 3 months)