Response to NonInvasive Mechanical Ventilation According to the Breathing Pattern
Not Applicable
Withdrawn
- Conditions
- Neuromuscular DisordersObesity Hypoventilation Syndrome (OHS)Chest Wall Disorders
- Registration Number
- NCT01991535
- Lead Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
- Brief Summary
The purpose of this study is to determine whether breathing pattern (specifically the inspiratory time/total respiratory cycle value) has an influence over the response to the noninvasive mechanical ventilation.
- Detailed Description
Breathing pattern will be analyzed along the adaptation to 3 different NonInvasive-Mechanical-Ventilation modes (controlled mode, spontaneous mode and placebo mode or simulator).
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Hypercapnic chronic respiratory failure due to restrictive pulmonary disease (with usual criteria for home NonInvasive Mechanical Ventilation).
- Transcutaneous carbon dioxide (CO2) basal pressure ≥ 50 mmHg when conscious.
- Clinically stable (within the previous month).
- Patients without previous NonInvasive Mechanical Ventilation treatment.
Exclusion Criteria
- Clinical exacerbation.
- Chronic airflow limitation Forced expiratory volume in 1 second/Forced vital capacity (FEV1/FVC) ratio < 70% or Sleep Apnea-Hypopnea Syndrome
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Transcutaneous carbon dioxide measurement One hour
- Secondary Outcome Measures
Name Time Method Inspiratory-time/total-respiratory-cycle value One hour
Trial Locations
- Locations (1)
Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Spain