se of noninvasive ventilation (NIV) and high flow nasal therapy (HFNT) after early extubation in chest trauma patients

Recruiting

• Conditions: chest trauma; respiratory failure; Injuries and Accidents - Other injuries and accidents; Anaesthesiology - Other anaesthesiology; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12616001727437
• Lead Sponsor: niversity of Palermo. Pocliclinico P. Giaccone

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-12-16
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

All of the following:

1) age equal or higher than 18 years;
2) Invasive Mechanical Ventilation (iMV) for at least 24h;
3) pressure support ventilation (PSV) with a total applied pressure, i.e. positive end-expiratory pressure (PEEP) inspiratory support, < 20 cmH2O and a PEEP level between 8 and 10 cmH2O;
4) PaO2/FiO2 between 200 and 300 mmHg
5) PaCO2 < 45mmHg and pH > 7.35;
6) respiratory rate (RR) < 30/min;
7) core temperature < 38.5 degree Celtius; (8)
8) Glasgow coma scale (GCS) equal or higher than 11;
9) Richmond Agitation Sedation Score < 3;
10) cough on suctioning and need for tracheobronchial suctioning less than 2 per hour.

Exclusion Criteria

One of the following:

1) hemodynamic instability i.e. systolic arterial pressure < 90 mmHg despite fluid repletion;
2) use of vasoactive agents, i.e. vasopressin, epinephrine and norepinephrine at any dosage, and dopamine or dobutamine > 5mcg/kg/min;
3) life-threatening arrhythmias or electrocardiographic signs of ischemia;
4) sepsis or septic shock;
5) ARF secondary to neurological disorders, status asthmaticus, COPD, cardiogenic pulmonary oedema;
6) presence of tracheotomy;
7) uncontrolled vomiting;
8) uncontrolled agitation RASS >3 5;
9) two or more organ failures;
10) body mass index > 30;
11) documented history or suspicion of obstructive sleep apnoea;
12) unstable flail chest
13) recent upper airway or esophageal surgery
14) ongoing pregnancy
15) inclusion in other research protocols.

Study & Design

• Study Type: Interventional
• Study Design: Not specified