Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma
- Conditions
- SarcomaKidney CancerOvarian CancerMetastatic CancerMelanoma (Skin)
- Registration Number
- NCT00003308
- Lead Sponsor
- Eastern Cooperative Oncology Group
- Brief Summary
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells.
PURPOSE: Phase II trial to study the effectiveness of radiation therapy in treating patients with newly diagnosed brain metastases from kidney cancer, melanoma, or sarcoma.
- Detailed Description
OBJECTIVES:
* Evaluate whether the delivery of stereotactic radiosurgery without conventional whole brain radiotherapy is feasible in patients with 1-3 newly diagnosed brain metastases from renal cell carcinoma, melanoma, or sarcoma.
* Determine the 3-, 6-, and 12-month radiographic and neurologic intracranial patterns of progression (i.e., original lesions vs new lesions) in patients treated with this regimen.
OUTLINE: This is a multicenter study. Patients are stratified according to maximum tumor diameter (2 cm vs greater than 2 cm to 3 cm vs greater than 3 cm to 4 cm).
Patients undergo stereotactic radiosurgery at an assigned dose according to tumor diameter. Patients undergo MRI or CT scan at 3, 6, and 12 months after treatment or until disease progression.
All other therapies are allowed after stereotactic radiosurgery except external beam whole brain radiotherapy or resection of brain metastases, unless there is documented progression or unrelenting mass effect that necessitates craniotomy.
Patients are followed every 3 months for 2 years.
PROJECTED ACCRUAL: A total of 36 patients will be accrued for this study within 7.2 months.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (14)
Iowa Methodist Medical Center
🇺🇸Des Moines, Iowa, United States
Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
Veterans Affairs Medical Center - Madison
🇺🇸Madison, Wisconsin, United States
Mercy Medical Center
🇺🇸Des Moines, Iowa, United States
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
Alegent Health-Midlands Community Hospital
🇺🇸Papillion, Nebraska, United States
Iowa Lutheran Hospital
🇺🇸Des Moines, Iowa, United States
CCOP - Kalamazoo
🇺🇸Kalamazoo, Michigan, United States
Ireland Cancer Center
🇺🇸Cleveland, Ohio, United States
CCOP - St. Vincent Hospital Cancer Center, Green Bay
🇺🇸Green Bay, Wisconsin, United States
University of Wisconsin Comprehensive Cancer Center
🇺🇸Madison, Wisconsin, United States
Instituto de Enfermedades Neoplasicas
🇵🇪Lima, Peru
San Juan City Hospital
🇵🇷San Juan, Puerto Rico
MBCCOP - University of New Mexico HSC
🇺🇸Albuquerque, New Mexico, United States