Anatomical Landmarks for Chest Wall Perforators Used for Partial Breast Reconstruction

Not yet recruiting

• Conditions: Breast Cancer Female

• Registration Number: NCT07006662
• Lead Sponsor: University Hospitals of North Midlands NHS Trust

Brief Summary

The aim of this 6-month proof-of-concept study is to map out the chest wall perforators in relation to anatomical landmarks for partial breast reconstruction.

Detailed Description

Breast conserving surgery is commonly performed in patients with breast cancer. It is important to fill the defect from a breast conserving procedure to achieve good cosmetic outcome. This defect can be filled either by using the adjacent breast tissue or by using perforator flaps; commonly taken from the area posterolateral to the breast or or below the inframammary crease. These perforator flaps can be based on thoracodorsal artery, lateral thoracic artery, lateral intercostal artery or the medial intercostal artery. The identification of these perforators using a hand-held doppler is an important but time-consuming intraoperative step. Surgeons often use the information derived from cadaveric studies when identifying these perforators as there is minimal information on the location of these perforators in relation to anatomical landmarks.

Patients with a BMI of \< 25 Kg/m2admitted for elective breast surgery or attending breast outpatients' clinic will be included in the study. Patients will be sent information about this study prior to admission or the clinic appointment with a copy of the consent form. Participants will have a 30-minute assessment using a hand held doppler and perforators will be mapped against soft tissue and bony landmarks. Data will be analysed to identify common anatomical locations for the different chest wall perforators.

Study Timeline

• Study First Submitted: 2025-05-27
• Study First Submitted QC: 2025-05-27
• Study First Posted: 2025-06-05
• Status Verified: 2025-08
• Last Update Submitted: 2025-08-05
• Last Update Posted: 2025-08-06
• Study Start: 2025-10-01
• Primary Completion: 2026-01-01
• Study Completion: 2026-01-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

• Patients undergoing elective breast surgery
• Age ≥ 18 years
• Female
• BMI ≤ 30 kg/m2
• Willing and able to give fully informed consent,
• Willing and able to comply with the study procedures

Exclusion Criteria

• Pregnant patients
• Previous bilateral Breast or axillary surgery
• Undergoing bilateral oncoplastic procedure or requiring bilateral pre-operative marking
• Undergoing breast surgery requiring pre-operative marking of some of the landmarks and has had contralateral breast or axillary surgery in the past
• Surgery planned within 24 hours of screening for eligibility
• Known history of allergy or contact dermatitis to ultrasound gels

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Location of vesselse	6 months	The location of the AICAP vessels in vertical and horizontal axis using constant bony and soft tissue landmarks. This will be measured by the distance of the perforators from the anatomical landmarks
Location of vessels	6 months	The location of the LICAP vessels in vertical and horizontal axis using constant bony and soft tissue landmarks. This will be measured by the distance of the perforators from the anatomical landmarks

Secondary Outcome Measures

Name	Time	Method
Variability	6 months	The degree of variability in location of the perforators.

Trial Locations

Locations (1)

University Hospitals of North Midlands NHS Trust; 🇬🇧 Stoke-on-Trent, United Kingdom