Development of a novel opioid-free anesthesia protocol for laparoscopic surgery
Not Applicable
Completed
- Conditions
- Intraoperative and postoperative pain control in laparoscopic abdominal surgerySurgery
- Registration Number
- ISRCTN15228105
- Lead Sponsor
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone di Palermo
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 379
Inclusion Criteria
Consecutive patients older than 18 years old who planned for laparoscopic scheduled abdominal surgery and will undergo general anesthesia
Exclusion Criteria
1. Age below 18 years old
2. Pregnant women
3. Confirmed diagnosis of hypermagnesemia, hyponatremia, hypocalcemia, hyperkalemia
4. Acidosis states
5. Acute or chronic kidney disease
6. Hypothyroidism
7. Hypoadrenocorticism
8. Neuromuscular disorders
9. Bradycardia
10. Bradyarrhythmia
11. Atrioventricular block
12. Pacemaker
13. Heart failure associated with hypotension and reduced cardiac function
14. Shock
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain measured using a Numerical Rating Scale (NRS) in the postoperative period at the end of surgery (T0) and at 6 (T1)-12 (T2)-18 (T3)-24 (T4) hours
- Secondary Outcome Measures
Name Time Method Composite of postoperative adverse events such as hypoxemia, defined as a SpO2 level of less than 95% with a need for oxygen supplementation; postoperative ileus, defined as an absence of flatus or stools; postoperative nausea and vomiting with the need for rescue antiemetic medication, unplanned intensive care unit (ICU) admission, mobilization recovery time and in-hospital length of stay measured using patient study records within the first 24 hours after extubation