Molecular Characterization of Patients With Acute Myeloid Leukemia and the Impact of Clonal Evolution in the Response to Therapeutic Treatments
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myeloid Leukemia, Acute
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Refractoriness to therapy
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
This study aims to analyze patients with mutated FLT3 AML treated with specific therapy by means of molecular characterization methods, to identify the presence of clones and subclones at onset and to be able to follow their evolution during therapeutic treatment.
Detailed Description
This study aims to analyze patients with mutated FLT3 AML treated with specific therapy by means of single-cell molecular characterization methods, to identify the presence of clones and subclones at onset and to be able to follow their evolution during therapeutic treatment. In this way, it is possible to study how the mutational profile varies under therapeutic pressure and identify any alterations responsible for resistance. It will thus be possible to define a panel of new molecular markers to be included in the diagnostic routine to identify early patients refractory/resistant to treatment with FLT3 inhibitors and thus improve the therapeutic approach of these patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •FLT3 mutated
Exclusion Criteria
- •Respoder to therapy
Outcomes
Primary Outcomes
Refractoriness to therapy
Time Frame: At the end of the enrollment 3 years
Selected patients, as they are mutated in FLT3, following therapy with specific inhibitors must show refractoriness to treatment in order to continue the study and investigate in single cell the presence of clones or subclones responsible for any relapses.