Dilated Perivascular Spaces in the Dentate Nucleus on MRI in Patients With Hypertensive Angiopathy or Cerebral Amyloid Angiopathy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 72
- 试验地点
- 2
- 主要终点
- hypercholesterolemia
研究概览
简要总结
Hypertensive arteriopathy (HA) and cerebral amyloid angiopathy (CAA) are the two most common forms of cerebral small vessel disease. On MRI, chronic small vessel disease-related abnormalities include white matter hyperintensities, dilated perivascular spaces (DPVS), lacunar infarction, and hemorrhagic features (e.g. cerebral microbleeds, CMB). In the cerebellum, deep CMB involving the dentate nucleus (DN) is associated with HA, whereas the presence of superficial cerebellar CMB are associated with CAA. DPVS are observed in both diseases, predominant in the subcortical white matter (especially in the centrum semiovale) in CAA whereas HA-related DPVS are predominant deep in the brain inside or nearby the basal ganglia.
To the best of our knowledge, DN-DPVS have never been studies systematically in small vessel disease. The researchers want to study DN-DPVS on T2-weighted 3T MRI in patients with HA or CAA and to compare both groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient registered in the CHU de Nîmes (France) stroke database with lobar intracerebral hemorrhage [ICH], subarachnoid hemorrhage or cortical superficial siderosis for CAA or basal ganglion ICH for HA
- •Patient managed at the CHU de Nîmes (France) between 01/1/2015 and 31/12/2024
- •Patient with T2-weighted MRI performed with a 3T magnet
排除标准
- •Refusal to participate
结局指标
主要结局
hypercholesterolemia
时间窗: baseline
history of hypercholesterolemia (Yes/No)
Sex
时间窗: baseline
Comparaison of both populations (HA/CAA), H/F
Hypertension
时间窗: baseline
history of hypertension (Yes/No)
Age
时间窗: baseline
Age at time of T2-weighted imaging,
Time
时间窗: baseline
Time between initial MRI-based CAA/HA diagnosis and 3T T2-weighted imaging, axial or coronal views of T2 imaging,
MRI view
时间窗: baseline
T2 performed using coronal or axial imaging (axial / coronal
Hemorrhagic lesion
时间窗: baseline
Hemorrhagic lesion load on T2\*-weighted imaging (ICH and CMB for both CAA and HA, and subarachnoid hemorrhage/cortical superficial siderosis for CAA)
Subcortical lobar DPVS
时间窗: baseline
Semi-quantitative score for evaluation of subcortical lobar DPVS (0 if DPVS are absent, 1 if 1 to 10 DPVS are visible, 2 for 11 to 20 DPVS, 3 for 21 to 40 DPVS, and 4 for \>40 DPVS).
DPVS of basal ganglia
时间窗: baseline
Semi-quantitative score for evaluation of DPVS of basal ganglia (0 if DPVS are absent, 1 if 1 to 10 DPVS are visible, 2 for 11 to 20 DPVS, 3 for 21 to 40 DPVS, and 4 for \>40 DPVS).
Diabete
时间窗: baseline
history of diabetes (Yes/No)
Smoking
时间窗: Baseline
current smoking (Yes / No)
次要结局
未报告次要终点