Single vs split dose of prednisolone in the treatment relapses of childhood nephrotic syndrome: A Randomized Controlled Trial
Phase 4
- Conditions
- ephrotic syndrome
- Registration Number
- SLCTR/2019/025
- Lead Sponsor
- Teaching hospital, Peradeniya
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
•Male and female
•Between 1 and 14 years of age
•With idiopathic nephrotic syndrome
•Admitted to the unit with a relapse
Exclusion Criteria
* Patients with steroid resistant nephrotic syndrome
* Patients with secondary nephrotic syndrome
* Patients who have been started on treatment for the 1st episode/relapse prior to the admission to our unit
* Patients with deranged renal functions
* Patients with other associated co morbidities
* Presented with first episode of nephrotic syndrome
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Remission is defined as a urine test with nil or trace proteinuria for 3 consecutive days. <br>Urine albumin test will be checked every day only from early morning urine sample for assessment of remission<br><br>Number of days until a remission will be used to compare the test group and the control group<br> [Daily urine analysis and date of remission (for number of days for remission after introducing the intervention) ]<br>
- Secondary Outcome Measures
Name Time Method Proportion of patients on second line medicine/s who achieved remissions in < 5 days<br><br>Proportion of patients not on second line medicine/s who achieved remissions in < 5 days [At study completion]<br>