Randomized Study in Children and Adolescents With Migraine: Acute Treatment
- Conditions
- Pediatric Migraine
- Interventions
- Drug: Rimegepant/BHV3000Drug: Matching placebo
- Registration Number
- NCT04649242
- Lead Sponsor
- Pfizer
- Brief Summary
The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 2100
-
History of migraine (with or without aura) for > 6 months before Screening according to the IHS Classification ICHD-319 specifications for pediatric migraine. History may be verified using both medical records and recall by the participant and/or participant's parent(s)/legal representative(s).
-
History of 1 to 8 moderate or severe attacks per month during the 2 months prior to enrollment, with attacks lasting > 3 hours without treatment, and attacks occurring at intervals > 24 hours.
-
Prophylactic migraine medication are permitted if the dose has been stable for at least 12 weeks prior to the Baseline Visit, and the dose is not expected to change during the course of the study.
- Participants may remain on one (1) medication with possible migraine prophylactic effects, excluding CGRP antagonists [biologic or small molecule], during the treatment phases.
- Concomitant use of a CGRP antagonist, such as erenumab or fremanezumab, is prohibited.
- Previously discontinued prophylactic migraine medication must have done so at least 90 days prior to the Screening Visit.
-
Verbally distinguish between migraine and other types of headaches.
-
Participants must have a weight > 40 kg at the Screening Visit.
-
Adequate venous access for blood sampling.
-
Male and female participants ≥ 6 to < 18 years of age (participants must not reach their 18th birthday during the study).
- History of cluster headache or hemiplegic migraine headache.
- Confounding and clinically significant pain syndrome that may interfere with the participant's ability to participate in this study.
- Current psychiatric condition that is uncontrolled and/or untreated for a minimum of 6 months prior to the Screening Visit. Participants with a lifetime history of psychosis and/or mania.
- History of suicidal behavior or major psychiatric disorder.
- Current diagnosis or history of substance abuse; positive drug test at Screening.
- History of moderate or severe head trauma or other neurological disorder (including seizure disorder) or systemic medical disease that is likely to affect central nervous system functioning.
- Recent or planned surgery, requiring general anesthesia, <8 weeks prior to the Screening Visit.
- Participant has had gastrointestinal surgery that interferes with physiological absorption and motility (i.e., gastric bypass, duodenectomy, or gastric banding).
- Current diagnosis of viral hepatitis or a history of liver disease.
- Conditions considered clinically relevant in the context of the study such as uncontrolled hypertension (high blood pressure), diabetes, a life-threatening allergy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description BHV3000 (active drug) Rimegepant/BHV3000 BHV3000 (rimegepant) 75 mg or 50 mg ODT Placebo Matching placebo Matching 75 mg or 50 mg ODT placebo
- Primary Outcome Measures
Name Time Method To evaluate the efficacy of rimegepant compared with placebo in the acute treatment of migraine in adolescent population (≥ 12 to <18 years of age) as measured by pain freedom using the number of patients reporting no pain. 2 hours post-dose Pain freedom will be assessed in adolescent population (≥ 12 to \< 18 years of age) on a 4-point numeric rating scale (0=none, 1=mild, 2=moderate, 3=severe).
- Secondary Outcome Measures
Name Time Method To compare rimegepant with placebo on the probabilities of requiring rescue medication in children and combined children and adolescents. Within 24 hours and 48 hours of initial treatment. The probabilities of requiring rescue medication will be assessed using the numbers of participants that take rescue medication within initial treatment.
To compare rimegepant with placebo on freedom from nausea in adolescents, children and combined children and adolescents. 2 hours post-dose Freedom from nausea will be assessed by the number of participants that report the absence of nausea post dose that reported the presence of nausea at baseline.
To compare rimegepant with placebo on pain relief in adolescents, children and combined children and adolescents. 2 hours post-dose Pain relief will be assessed using the number of participants that report a pain level of moderate or severe at baseline and then report a pain level of none or mild post dose.
To compare rimegepant with placebo on sustained pain freedom in adolescents. 2 to 48 hours post-dose Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
To compare rimegepant with placebo on the ability to function normally as reported on the Functional Disability scale in adolescents. 2 hours post-dose The proportion of participants able to function normally will be assessed using the number that self-report as "normal" on the Functional Disability scale.
To compare rimegepant with placebo for pain freedom in children and adolescents combined. 2 hours post-dose Pain freedom will be assessed in children and adolescents (≥ 6 to \< 18 years of age) using a 4-point numeric rating scale (0=none, 1=mild, 2=moderate, 3=severe).
Pain freedom will be assessed in children (\> 6 to \< 12 years of age) using the 5-Face VAS (Face 5 = 'severe pain', Faces 4 and 3 = 'moderate pain', Face 2 = 'mild pain', Face 1 = 'no pain').To compare rimegepant with placebo on freedom from the most bothersome symptom (MBS) associated with migraine in adolescents. 2 hours post-dose Freedom from MBS (nausea, phonophobia or photophobia) will be measured using a binary scale (0=absent, 1=present).
To compare rimegepant with placebo on the probabilities of requiring rescue medication within in adolescents. Within 24 hours and 48 hours of initial treatment Use of rescue medication will be assessed using the numbers of participants that take rescue medication.
To compare rimegepant with placebo for pain freedom in children. 2 hours post-dose Pain freedom will be assessed using the number of children (≥ 6 to \< 12 years of age) that report no pain measured by a 5-Face VAS (Face 5 = 'severe pain', Faces 4 and 3 = 'moderate pain', Face 2 = 'mild pain', Face 1 = 'no pain').
To compare rimegepant with placebo on freedom from the most bothersome symptom (MBS) associated with migraine in children and combined children and adolescents. 2 hours post-dose Freedom from the most bothersome symptom (nausea, phonophobia or photophobia) will be assessed using the number of participants that report the absence of MBS measured using a binary scale (0=absent, 1=present).
To compare rimegepant with placebo in adolescents, children and combined children and adolescents on pain relief. Time to patients first report of pain relief of none or mild post dose up to 48 hours. Time to first report of pain relief will be based on the first time point a participant reports a pain level of none or mild.
To compare rimegepant with placebo on sustained pain freedom in children and combined children and adolescents. 2 to 48 hours post-dose Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
To compare rimegepant with placebo on freedom from photophobia in adolescents, children and combined children and adolescents. 2 hours post-dose Freedom from photophobia will be assessed by the number of participants that report the absence of photophobia post dose that reported the presence of photophobia at baseline.
To compare rimegepant with placebo on freedom from phonophobia in adolescents, children and combined children and adolescents. 2 hours post-dose Freedom from phonophobia will be assessed by the number of participants that report the absence of phonophobia post dose that reported the presence of phonophobia at baseline.
Trial Locations
- Locations (266)
Nicklaus Children's Hospital, Research Institute
🇺🇸Miami, Florida, United States
Nicklaus Children's Hospital
🇺🇸Miami, Florida, United States
Accel Research Sites-Neurology and Neurodiagnostics of Alabama, LLC
🇺🇸Birmingham, Alabama, United States
Phoenix Children's Hospital
🇺🇸Phoenix, Arizona, United States
Perseverance Research Center, LLC
🇺🇸Scottsdale, Arizona, United States
Physicians Research Group
🇺🇸Noblesville, Indiana, United States
Advanced Research Center, Inc.
🇺🇸Anaheim, California, United States
Velocity Clinical Research, Banning
🇺🇸San Bernardino, California, United States
ProScience Research Group
🇺🇸Culver City, California, United States
Neuro-Pain Medical Center
🇺🇸Fresno, California, United States
University of California, San Diego Altman Clinical Translational Research Institute
🇺🇸La Jolla, California, United States
Sunwise Clinical Research, LLC
🇺🇸Lafayette, California, United States
Miller Children's & Women's Hospital Long Beach
🇺🇸Long Beach, California, United States
Children's Hospital Los Angeles, Division of Neurology
🇺🇸Los Angeles, California, United States
Children's Hospital Los Angeles-Children's Hospital Los Angeles Dept of Pharmacy
🇺🇸Los Angeles, California, United States
National Research Institute
🇺🇸Los Angeles, California, United States
Velocity Clinical Research - North Hollywood
🇺🇸North Hollywood, California, United States
The Neurology Group
🇺🇸Pomona, California, United States
University of California, Davis Midtown Clinic
🇺🇸Sacramento, California, United States
UC Davis Medical Center, Investigational Drug Service (IDS) Pharmacy
🇺🇸Sacramento, California, United States
University of California, Davis Clinical and Translational Science Center Clinical Research (CCRC)
🇺🇸Sacramento, California, United States
Pacific Clinical Research Management Group LLC
🇺🇸Upland, California, United States
Children's Hospital Colorado- lnvestigational Drug Services
🇺🇸Aurora, Colorado, United States
Children's Hospital Colorado
🇺🇸Aurora, Colorado, United States
Colorado Springs Neurological Associates
🇺🇸Colorado Springs, Colorado, United States
Boeson Research
🇺🇸Missoula, Montana, United States
Dinosaur Junction Pediatrics
🇺🇸Grand Junction, Colorado, United States
Boeson Research - Grand Junction, CO
🇺🇸Grand Junction, Colorado, United States
CT Clinical Research
🇺🇸Cromwell, Connecticut, United States
Connecticut Children's Medical Center
🇺🇸Hartford, Connecticut, United States
Ki Health Partners, LLc, dba New England Institute for Clinical Research
🇺🇸Stamford, Connecticut, United States
Nemours Children's Health
🇺🇸Wilmington, Delaware, United States
Nemours Children's Hospital, Delaware
🇺🇸Wilmington, Delaware, United States
Children's National Medical Center
🇺🇸Washington, District of Columbia, United States
Coastal Clinical Research Specialists
🇺🇸Orange Park, Florida, United States
Topaz Clinical Research, Inc.
🇺🇸Apopka, Florida, United States
First Choice Neurlogy Espinosa Neuroscience Institute
🇺🇸Boca Raton, Florida, United States
Beautiful Minds Clinical Research Center
🇺🇸Cutler Bay, Florida, United States
DeLand Clinical Research Unit
🇺🇸DeLand, Florida, United States
University Clinical Research - Deland, LLC dba Accel Research Sites
🇺🇸DeLand, Florida, United States
Sarkis Clinical Trials
🇺🇸Gainesville, Florida, United States
Multi-Specialty Research Associates, Inc.
🇺🇸Lake City, Florida, United States
Watson Clinic Center for Research, Inc.
🇺🇸Lakeland, Florida, United States
Watson Clinic LLP
🇺🇸Lakeland, Florida, United States
South Florida Research Phase I-IV, Inc
🇺🇸Miami Springs, Florida, United States
AppleMed Research Group, LLC
🇺🇸Miami, Florida, United States
Medical Research Center of Miami II, Inc
🇺🇸Miami, Florida, United States
Genoma Research Group, Inc.
🇺🇸Miami, Florida, United States
Brainstorm Research
🇺🇸Miami, Florida, United States
The Neurology Research Group
🇺🇸Miami, Florida, United States
Advanced Research for Health Improvement, LLC/ Dr. Cordero's Pediatric Office
🇺🇸Naples, Florida, United States
Aqualane Clinical Research
🇺🇸Naples, Florida, United States
Collier Neurologic Specialists, LLC
🇺🇸Naples, Florida, United States
Orlando Health Arnold Palmer Hospital for Children-Pediatric Specialty Practice
🇺🇸Orlando, Florida, United States
Orlando Health Arnold Palmer Hospital for Children
🇺🇸Orlando, Florida, United States
Bioresearch Institute
🇺🇸Pembroke Pines, Florida, United States
Forcare Clinical Research
🇺🇸Tampa, Florida, United States
Premiere Research Institute at Palm Beach Neurology
🇺🇸West Palm Beach, Florida, United States
Children's Healthcare of Atlanta Center for Advanced Pediatrics
🇺🇸Atlanta, Georgia, United States
Rare Disease Research, LLC
🇺🇸Atlanta, Georgia, United States
Pivotal Clinical Research & Associates, LLC
🇺🇸Brunswick, Georgia, United States
CenExel iResearch, LLC
🇺🇸Decatur, Georgia, United States
Chicago Headache Center & Research Institute
🇺🇸Chicago, Illinois, United States
AMR-Baber Research Inc
🇺🇸Naperville, Illinois, United States
Children's Clinical Research Center at Riley Hospital for Children at IU Health
🇺🇸Indianapolis, Indiana, United States
Riley Hospital for Children at IU Health
🇺🇸Indianapolis, Indiana, United States
Options Research Group, LLC
🇺🇸Westfield, Indiana, United States
Meridian Clinical Research, LLC
🇺🇸Charleston, South Carolina, United States
Integrated Clinical Trial Services
🇺🇸West Des Moines, Iowa, United States
Clinical Associates Midwest, LLC
🇺🇸Kansas City, Kansas, United States
College Park Family Care Center Physicians Group- Neurology Research Dept.
🇺🇸Overland Park, Kansas, United States
Kentucky Neuroscience Institute Child Neurology-- "Patients Seen"
🇺🇸Lexington, Kentucky, United States
UK Center for Clinical and Translational Science (CCTS) -- "Patients Seen"
🇺🇸Lexington, Kentucky, United States
University of Kentucky Hospital
🇺🇸Lexington, Kentucky, United States
Ochsner Clinic Foundation
🇺🇸New Orleans, Louisiana, United States
Neurology and Headache Center, Inc.
🇺🇸Shreveport, Louisiana, United States
Boston Clinical Trials
🇺🇸Boston, Massachusetts, United States
MedVadis Research Corporation
🇺🇸Waltham, Massachusetts, United States
Boeson Research LLC
🇺🇸Kalispell, Montana, United States
Michigan Head Pain & Neurological Institute
🇺🇸Ann Arbor, Michigan, United States
Corewell Health, for and on behalf of Spectrum Health Hospital and Corewell Health Medical Group
🇺🇸Grand Rapids, Michigan, United States
Corewell Health, Helen DeVos Children's Hospital
🇺🇸Grand Rapids, Michigan, United States
Outpatient Pediatric Neurology Clinic
🇺🇸Grand Rapids, Michigan, United States
Spectrum Health Helen Devos Children's Hospital
🇺🇸Grand Rapids, Michigan, United States
Wellnow Urgent Care and Research
🇺🇸Columbus, Ohio, United States
Beaumont Hospital Royal Oak Campus
🇺🇸Royal Oak, Michigan, United States
Precise Research Centers
🇺🇸Flowood, Mississippi, United States
Sharlin Health Neuroscience Research Center
🇺🇸Ozark, Missouri, United States
Clinvest Research, LLC
🇺🇸Springfield, Missouri, United States
Northwest Physicians
🇺🇸Great Falls, Montana, United States
Boeson Research HLN
🇺🇸Helena, Montana, United States
Blue Moose Pediatrics
🇺🇸Missoula, Montana, United States
Helena Pediatric Clinic P.C.
🇺🇸Helena, Montana, United States
Alivation Research, LLC.
🇺🇸Lincoln, Nebraska, United States
Children's Hospital & Medical Center
🇺🇸Omaha, Nebraska, United States
Dent Neurosciences Research Center
🇺🇸Amherst, New York, United States
Prime Global Research, LLC
🇺🇸Bronx, New York, United States
Northwell Health/ Division of Pediatric Neurology
🇺🇸Lake Success, New York, United States
New Hope Clinical Research
🇺🇸Charlotte, North Carolina, United States
NYU Langone Hospital-Long Island, Clinical Research Center
🇺🇸Mineola, New York, United States
NYU Langone Hospital-Long Island, Pediatric Neurology
🇺🇸Mineola, New York, United States
New York Neurology Associates
🇺🇸New York, New York, United States
Mount Sinai Hospital - Pharmacy Department
🇺🇸New York, New York, United States
Columbia University Medical Center Research Pharmacy
🇺🇸New York, New York, United States
Columbia University Pediatric Neuromuscular Center
🇺🇸New York, New York, United States
Irving Center for Clinical and Translational Research, Outpatient Clinical Research Unit
🇺🇸New York, New York, United States
The Neurological Institute of New York
🇺🇸New York, New York, United States
North Suffolk Neurology P.C
🇺🇸Port Jefferson Station, New York, United States
Finger Lakes Clinical Research
🇺🇸Rochester, New York, United States
Headache Wellness Center, PC
🇺🇸Greensboro, North Carolina, United States
Headache Wellness Center
🇺🇸Greensboro, North Carolina, United States
Atrium Health Wake Forest Baptist
🇺🇸Winston-Salem, North Carolina, United States
Cincinnati Children's Hospital Medical Center
🇺🇸Cincinnati, Ohio, United States
Akron Children's Hospital
🇺🇸Akron, Ohio, United States
Drug Delivery - Cincinnati Children's Hospital IDS - Denise Lagory
🇺🇸Cincinnati, Ohio, United States
Velocity Clinical Research
🇺🇸Cincinnati, Ohio, United States
University Hospitals Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
Neuro-Behavioral Clinical Research, Inc.
🇺🇸North Canton, Ohio, United States
Nationwide Children's Hospital
🇺🇸Columbus, Ohio, United States
IPS Research Company
🇺🇸Oklahoma City, Oklahoma, United States
Lynn Institute of Tulsa
🇺🇸Tulsa, Oklahoma, United States
Velocity Clinical Research, Grants Pass
🇺🇸Grants Pass, Oregon, United States
Providence Health & Services Investigational Drug Services Westside
🇺🇸Portland, Oregon, United States
Providence Brain & Spine Institute-research coordinator's office
🇺🇸Portland, Oregon, United States
Providence Pediatric Neurology
🇺🇸Portland, Oregon, United States
Providence St. Vincent Medical Center
🇺🇸Portland, Oregon, United States
Coastal Carolina Research Center
🇺🇸North Charleston, South Carolina, United States
Children's Hospital of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Velocity Clinical Research-Providence
🇺🇸East Greenwich, Rhode Island, United States
Premier Neurology, PC
🇺🇸Greenville, South Carolina, United States
Tribe Clinical Research, LLC
🇺🇸Greenville, South Carolina, United States
Velocity Clinical Research - Greenville
🇺🇸Greenville, South Carolina, United States
Holston Medical Group.
🇺🇸Kingsport, Tennessee, United States
Holston Medical Group
🇺🇸Kingsport, Tennessee, United States
Le Bonheur Children's Hospital
🇺🇸Memphis, Tennessee, United States
Access Clinical Trials, Inc.
🇺🇸Nashville, Tennessee, United States
Dell Children's Medical Center
🇺🇸Austin, Texas, United States
Child Neurology Consultants of Austin - South Austin
🇺🇸Austin, Texas, United States
Child Neurology Consultants of Austin - Central Austin
🇺🇸Austin, Texas, United States
BioBehavioral Research of Austin
🇺🇸Austin, Texas, United States
Houston Clinical Trials, LLC
🇺🇸Bellaire, Texas, United States
Future Search Trials of Dallas, LP
🇺🇸Dallas, Texas, United States
Children's Medical Center, Dallas
🇺🇸Dallas, Texas, United States
Children's Medical Center, Pediatric Anesthesiology Research (Study supplies only)
🇺🇸Dallas, Texas, United States
Cedar Health Research
🇺🇸Dallas, Texas, United States
ANESC Research
🇺🇸El Paso, Texas, United States
ANRC Research
🇺🇸El Paso, Texas, United States
North Texas Institute of Neurology and Headache
🇺🇸Frisco, Texas, United States
UTHealth Houston
🇺🇸Houston, Texas, United States
Pain and Headache Centers of Texas
🇺🇸Houston, Texas, United States
SCLA Management
🇺🇸Houston, Texas, United States
Houston Clinical Research,LLC.
🇺🇸Houston, Texas, United States
NeuroCare Plus
🇺🇸Houston, Texas, United States
AIM Trials, LLC
🇺🇸Plano, Texas, United States
JBR Clinical Research
🇺🇸Salt Lake City, Utah, United States
Wasatch Clinical Research , LLC(Administrative Location)
🇺🇸Salt Lake City, Utah, United States
The University of Vermont Medical Center
🇺🇸Burlington, Vermont, United States
Pediatric Associates of Charlottesville, PLC (Private Pediatric Practice)
🇺🇸Charlottesville, Virginia, United States
Pediatric Research of Charlottesville, LLC (Regulatory Only)
🇺🇸Charlottesville, Virginia, United States
Pediatric Research of Charlottesville, LLC
🇺🇸Charlottesville, Virginia, United States
Children's Hospital of the King's Daughters
🇺🇸Norfolk, Virginia, United States
Children's Specialty Group, PLLC, Division of Childhood & Adolescent Neurology
🇺🇸Norfolk, Virginia, United States
National Clinical Research, Inc.
🇺🇸Richmond, Virginia, United States
Northwest Clinical Research Center
🇺🇸Bellevue, Washington, United States
Eastside Therapeutic Resource, Inc. dba Core Clinical Research
🇺🇸Everett, Washington, United States
Seattle Children's Hospital Investigational Drug Services
🇺🇸Seattle, Washington, United States
Seattle Children's Hospital
🇺🇸Seattle, Washington, United States
Seattle Children's Investigational Drug Service
🇺🇸Seattle, Washington, United States
Clinical Investigation Specialists, Inc
🇺🇸Kenosha, Wisconsin, United States
University Hospital
🇺🇸Madison, Wisconsin, United States
University of Wisconsin-Madison
🇺🇸Madison, Wisconsin, United States
OCT Research ULC
🇨🇦Kelowna, British Columbia, Canada
Diex Recherche Sherbrooke Inc
🇨🇦Sherbrooke, Quebec, Canada
Alpha Recherche Clinique
🇨🇦Quebec, Canada
First Affiliated Hospital of Bengbu Medical College Neurology
🇨🇳Bengbu, Anhui, China
Anhui Provincial Hospital
🇨🇳Hefei, Anhui, China
Chinese PLA General Hospital
🇨🇳Beijing, Beijing, China
" The First Affiliated Hospital of Chongqing Medical University"
🇨🇳Chongqing, Chongqing, China
Lanzhou University Second Hospital Lab
🇨🇳Lanzhou, Gansu, China
Lanzhou university second hospital
🇨🇳Lanzhou, Gansu, China
The First Hospital of Hebei Medical University
🇨🇳Shijiazhuang, Hebei, China
The Second Hospital of Hebei Medical University
🇨🇳Shijiazhuang, Hebei, China
People's Hospital of Zhengzhou
🇨🇳Zhengzhou, Henan, China
Jingzhou First People's Hospital
🇨🇳Jingzhou, Hubei, China
Renmin Hospital of Wuhan University
🇨🇳Wuhan City, Hubei, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China
The Second Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
Hunan Children's Hospital
🇨🇳Changsha, Hunan, China
The Third Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
The Second People's Hospital of Lianyungang
🇨🇳Lianyungang, Jiangsu, China
Shenzhen Children's Hospital
🇨🇳Shenzhen, Guangdong, China
Hainan General Hospital
🇨🇳Haikou, Hainan, China
The First Affiliated Hospital of Soochow University
🇨🇳Suzhou, Jiangsu, China
Wuxi Children's Hospital
🇨🇳Wuxi, Jiangsu, China
Yan 'an University Xianyang Hospital
🇨🇳Xianyang City, Shaanxi, China
Shandong Provincial Qianfoshan Hospital
🇨🇳Jinan, Shandong, China
Affiliated Hospital of Jiangnan University
🇨🇳Wuxi, Jiangsu, China
Xuzhou Children's Hospital
🇨🇳Xuzhou, Jiangsu, China
Affiliated Hospital of Jiangsu University
🇨🇳Zhenjiang, Jiangsu, China
The First Hospital of Jilin University, Pediatric Neurology
🇨🇳Changchun, Jilin, China
General Hospital of Ningxia Medical University
🇨🇳Yinchuan, Ningxia, China
Shaanxi Provincial People's Hospital
🇨🇳Xi'an, Shaanxi, China
Liaocheng People's Hospital
🇨🇳Liaocheng, Shandong, China
West China Hospital of Sichuan University
🇨🇳Chengdu, Sichuan, China
Children's Hospital of Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Ningbo Women and Children's Hospital
🇨🇳Ningbo, Zhejiang, China
The Second Affiliated Hospital of Wenzhou Medical University
🇨🇳Wenzhou, Zhejiang, China
Xi'an Gaoxin Hospital Neurology Department
🇨🇳Xi'an, Shaanxi, China
Affiliated Hospital of Chifeng University
🇨🇳Chifeng, China
Chongqing University Three Gorges Hospital
🇨🇳Chongqing, China
Lu 'an People's Hospital
🇨🇳Lu 'an, China
Shengjing Hospital of China Medical University
🇨🇳Shenyang, China
The First Affiliated Hospital of Shihezi University School of Medicine
🇨🇳Shihezi, China
Children's Hospital of Shanghai
🇨🇳Shanghai, China
Wuhan Children's Hospital
🇨🇳Wuhan, China
Medical Corporation Seikokai Takanoko Hospital
🇯🇵Matsuyama-shi, Ehime, Japan
Jinnouchi Neurosurgical Clinic
🇯🇵Kasuga-shi, Fukuoka, Japan
Ikeda Neurosurgical Clinic
🇯🇵Kasuga-shi, Fukuoka, Japan
Hikita Pediatric Clinic
🇯🇵Kiryu-shi, Gunma, Japan
Hiroshima City Hiroshima Citizens Hospital
🇯🇵Naka-ku Hiroshima-shi, Hiroshima, Japan
Yamaguchi Clinic
🇯🇵Nishinomiya-shi, Hyōgo, Japan
Konan Medical Center
🇯🇵Higashinada-ku Kobe-shi, Hyōgo, Japan
Mito Kyodo General Hospital
🇯🇵Mito-shi, Ibaraki, Japan
Tanaka Neurosurgical Clinic
🇯🇵Kagoshima-shi, Kagoshima, Japan
Sendai Headache and Neurology Clinic
🇯🇵Taihaku-ku Sendai-shi, Miyagi, Japan
Tennoji Dai Brain Clinic
🇯🇵Abeno-ku Osaka-shi, Osaka, Japan
Tominaga Clinic
🇯🇵Naniwa-ku, Osaka-shi, Osaka, Japan
Saitama Neuropsychiatric Institute
🇯🇵Chuo-ku Saitama-shi, Saitama, Japan
Tokyo Headache Clinic
🇯🇵Shibuya-ku, Tokyo, Japan
Tokyo Medical University Hospital
🇯🇵Shinjuku-ku, Tokyo, Japan
Local lndependent Administrative Corporation Hiroshima City Hospital Organization Hiroshima City
🇯🇵Hiroshima, Japan
Clinstile S.A. de C.V.
🇲🇽Col. Roma Norte, Ciudad DE Mexico, Mexico
Clinical Reseach Institute, S.C.
🇲🇽Tlalnepantla de Baz, Estado DE Mexico, Mexico
Investigación Biomedica para el Desarrollo de Farmacos S.A. de C.V.
🇲🇽Zapopan, Jalisco, Mexico
"Hospital Universitario "" Dr. Jose Eleuterio Gonzalez"" Edificio Barragan 3er Piso CITEN
🇲🇽Monterrey, Nuevo LEON, Mexico
CIT-Neuropsique, S.C.
🇲🇽Monterrey, Nuevo LEÓN, Mexico
Neurociencias Estudios Clinicos S.C.
🇲🇽Culiacan, Sinaloa, Mexico
Unidad de Investigacion en Salud de Chihuahua S.C.
🇲🇽Chihuahua, Mexico
MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak
🇵🇱Wroclaw, Dolnoslaskie, Poland
NZOZ Wielospecjalistyczna Poradnia Lekarska SYNAPSIS, Lech Szczechowski
🇵🇱Katowice, Poland
Oddzial Kliniczny Dzieci Starszych z Pododdzialami: Neurologicznym, Reumatologicznym
🇵🇱Krakow, Poland
Wojewdzki Specjalistyczny Szpital Dziecicy im. sw. Ludwika w Krakowie
🇵🇱Krakow, Poland
Wojewódzki Specjalistyczny Szpital Dzieciecy im. Sw. Ludwika w Krakowie, Apteka Szpitalna
🇵🇱Krakow, Poland
Wojewódzki Specjalistyczny Szpital Dzieciecy im. Sw. Ludwika w Krakowie
🇵🇱Krakow, Poland
Clinical Research Center Sp. z.o.o. Medic-R Spolka komandytowa
🇵🇱Poznan, Poland
Clinical Research Center Spolka z ograniczona odpowiedzialnoscia MEDIC-R Sp.k.
🇵🇱Poznań, Poland
Euromedis Sp. z o. o.
🇵🇱Szczecin, Poland
Centrum Medyczne Oporow
🇵🇱Wroclaw, Poland
Hospital Universitario Marqués de Valdecilla
🇪🇸Santander, Spain
Hospital Universitari Vall dHebron
🇪🇸Barcelona, Spain
Hospital Universitario Vall d'Hebron
🇪🇸Barcelona, Spain
CAP Balenyà
🇪🇸Barcelona, Spain
Centre d'Atencio Primaria Balenya
🇪🇸Barcelona, Spain
Instituto de Investigaciones del Sueno
🇪🇸Madrid, Spain
Hospital Universitario Virgen del Rocío
🇪🇸Sevilla, Spain
Hospital Clinico Universitario de Valladolid
🇪🇸Valladolid, Spain
ProbarE i Lund AB
🇸🇪Lund, Skåne LÄN [se-12], Sweden
ProbarE i Lund
🇸🇪Lund, Sweden
ProbarE i Stockholm AB
🇸🇪Stockholm, Sweden
Avdelningen för kliniska Prövningar, Universitetssjukhuset Örebro
🇸🇪Örebro, Sweden
Universitetssjukhuset Örebro
🇸🇪Örebro, Sweden
University Hospitals of Leicester - NHS Trust Research - Innovation Leicester General Hospital
🇬🇧Leicester, Leics, United Kingdom
Leicester Royal Infirmary
🇬🇧Leicester, United Kingdom
Re:Cognition Health Limited
🇬🇧London, United Kingdom
Great Ormond Street Hospital for Children NHS Foundation Trust
🇬🇧London, United Kingdom
Great Ormond Street Hospital GOSH for Children NHS Foundation Trust - Headache Clinic
🇬🇧London, United Kingdom