Assessment of Right Ventricular Function for Diagnosis and Prognosis After Acute Pulmonary Embolism: a Comparison of Speckle Tracking Strain and Conventional Echocardiographic Parameters
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Primary (main): Composite of in-hospital mortality, ICU admission >7 days, or need for mechanical circulatory/ventilatory support.
研究概览
简要总结
Echocardiographic Assessment:
Performed within 24h of PE diagnosis Conventional parameters: TAPSE, RV FAC, RV/LV ratio, tricuspid S', PASP STE parameters: RV free wall longitudinal strain (RVFWS), global longitudinal strain (GLS) if feasible All measurements averaged over 3 cardiac cycles (sinus) or 5 (AF)
Follow-up data:
ICU/hospital LOS Need for vasopressors/mechanical ventilation In-hospital and 30-day mortality
详细描述
the study targets patient with acute pulmonary embolism confirmed by CTPA, without hemodynamic instability. within the first 24 hours echocardiography will be conducted, assessment of RV function by conventional measures eg, TAPSE, S', FCA and speckle tracking strain echocardiography.
compare the results and its sensitivity in prediction of clinical outcomes, that will be assessed by follow up the patients for one month regarding length of hospital stay, oxygen/ventilatory support, hemodynamics support and 30 day mortality.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults ≥18 years.
- •Confirmed acute PE (via CT pulmonary angiography).(4,6)
- •Echocardiography performed within 24 hours of diagnosis.
排除标准
- •Pre-existing significant RV dysfunction (e.g., due to chronic pulmonary hypertension, cor pulmonale or congenital heart disease).
- •History of coronary artery disease.
- •Impaired LV systolic function, ejection fraction <50%.
- •Moderate to severe valvular heart disease.
- •Prior document of an episode of pulmonary embolism.
- •Poor acoustic window.
- •Hemodynamic instability
结局指标
主要结局
Primary (main): Composite of in-hospital mortality, ICU admission >7 days, or need for mechanical circulatory/ventilatory support.
时间窗: 30 day follow up
次要结局
- Secondary outcome: Each individual component; echocardiographic parameters as predictors.(30 day follow up)
研究者
Doaa Roshdy Abdul Satar Mohamed
assistant lecturer
Assiut University